Evolution of a Major Drug Metabolizing Enzyme Defect in the Domestic Cat and Other Felidae: Phylogenetic Timing and the Role of Hypercarnivory

The domestic cat (Felis catus) shows remarkable sensitivity to the adverse effects of phenolic drugs, including acetaminophen and aspirin, as well as structurally-related toxicants found in the diet and environment. This idiosyncrasy results from pseudogenization of the gene encoding UDP-glucuronosy...

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Detalles Bibliográficos
Autores principales: Shrestha, Binu, Reed, J. Michael, Starks, Philip T., Kaufman, Gretchen E., Goldstone, Jared V., Roelke, Melody E., O'Brien, Stephen J., Koepfli, Klaus-Peter, Frank, Laurence G., Court, Michael H.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3065456/
https://www.ncbi.nlm.nih.gov/pubmed/21464924
http://dx.doi.org/10.1371/journal.pone.0018046

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