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A Review on Composite Liposomal Technologies for Specialized Drug Delivery

The combination of liposomes with polymeric scaffolds could revolutionize the current state of drug delivery technology. Although liposomes have been extensively studied as a promising drug delivery model for bioactive compounds, there still remain major drawbacks for widespread pharmaceutical appli...

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Detalles Bibliográficos
Autores principales: Mufamadi, Maluta S., Pillay, Viness, Choonara, Yahya E., Du Toit, Lisa C., Modi, Girish, Naidoo, Dinesh, Ndesendo, Valence M. K.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3065812/
https://www.ncbi.nlm.nih.gov/pubmed/21490759
http://dx.doi.org/10.1155/2011/939851
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author Mufamadi, Maluta S.
Pillay, Viness
Choonara, Yahya E.
Du Toit, Lisa C.
Modi, Girish
Naidoo, Dinesh
Ndesendo, Valence M. K.
author_facet Mufamadi, Maluta S.
Pillay, Viness
Choonara, Yahya E.
Du Toit, Lisa C.
Modi, Girish
Naidoo, Dinesh
Ndesendo, Valence M. K.
author_sort Mufamadi, Maluta S.
collection PubMed
description The combination of liposomes with polymeric scaffolds could revolutionize the current state of drug delivery technology. Although liposomes have been extensively studied as a promising drug delivery model for bioactive compounds, there still remain major drawbacks for widespread pharmaceutical application. Two approaches for overcoming the factors related to the suboptimal efficacy of liposomes in drug delivery have been suggested. The first entails modifying the liposome surface with functional moieties, while the second involves integration of pre-encapsulated drug-loaded liposomes within depot polymeric scaffolds. This attempts to provide ingenious solutions to the limitations of conventional liposomes such as short plasma half-lives, toxicity, stability, and poor control of drug release over prolonged periods. This review delineates the key advances in composite technologies that merge the concepts of depot polymeric scaffolds with liposome technology to overcome the limitations of conventional liposomes for pharmaceutical applications.
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spelling pubmed-30658122011-04-13 A Review on Composite Liposomal Technologies for Specialized Drug Delivery Mufamadi, Maluta S. Pillay, Viness Choonara, Yahya E. Du Toit, Lisa C. Modi, Girish Naidoo, Dinesh Ndesendo, Valence M. K. J Drug Deliv Review Article The combination of liposomes with polymeric scaffolds could revolutionize the current state of drug delivery technology. Although liposomes have been extensively studied as a promising drug delivery model for bioactive compounds, there still remain major drawbacks for widespread pharmaceutical application. Two approaches for overcoming the factors related to the suboptimal efficacy of liposomes in drug delivery have been suggested. The first entails modifying the liposome surface with functional moieties, while the second involves integration of pre-encapsulated drug-loaded liposomes within depot polymeric scaffolds. This attempts to provide ingenious solutions to the limitations of conventional liposomes such as short plasma half-lives, toxicity, stability, and poor control of drug release over prolonged periods. This review delineates the key advances in composite technologies that merge the concepts of depot polymeric scaffolds with liposome technology to overcome the limitations of conventional liposomes for pharmaceutical applications. Hindawi Publishing Corporation 2011 2011-02-08 /pmc/articles/PMC3065812/ /pubmed/21490759 http://dx.doi.org/10.1155/2011/939851 Text en Copyright © 2011 Maluta S. Mufamadi et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Mufamadi, Maluta S.
Pillay, Viness
Choonara, Yahya E.
Du Toit, Lisa C.
Modi, Girish
Naidoo, Dinesh
Ndesendo, Valence M. K.
A Review on Composite Liposomal Technologies for Specialized Drug Delivery
title A Review on Composite Liposomal Technologies for Specialized Drug Delivery
title_full A Review on Composite Liposomal Technologies for Specialized Drug Delivery
title_fullStr A Review on Composite Liposomal Technologies for Specialized Drug Delivery
title_full_unstemmed A Review on Composite Liposomal Technologies for Specialized Drug Delivery
title_short A Review on Composite Liposomal Technologies for Specialized Drug Delivery
title_sort review on composite liposomal technologies for specialized drug delivery
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3065812/
https://www.ncbi.nlm.nih.gov/pubmed/21490759
http://dx.doi.org/10.1155/2011/939851
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