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Effectiveness analysis of resistance and tolerance to infection

BACKGROUND: Tolerance and resistance provide animals with two distinct strategies to fight infectious pathogens and may exhibit different evolutionary dynamics. However, few studies have investigated these mechanisms in the case of animal diseases under commercial constraints. METHODS: The paper pro...

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Detalles Bibliográficos
Autor principal: Detilleux, Johann C
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3066122/
https://www.ncbi.nlm.nih.gov/pubmed/21362170
http://dx.doi.org/10.1186/1297-9686-43-9
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author Detilleux, Johann C
author_facet Detilleux, Johann C
author_sort Detilleux, Johann C
collection PubMed
description BACKGROUND: Tolerance and resistance provide animals with two distinct strategies to fight infectious pathogens and may exhibit different evolutionary dynamics. However, few studies have investigated these mechanisms in the case of animal diseases under commercial constraints. METHODS: The paper proposes a method to simultaneously describe (1) the dynamics of transmission of a contagious pathogen between animals, (2) the growth and death of the pathogen within infected hosts and (3) the effects on their performances. The effectiveness of increasing individual levels of tolerance and resistance is evaluated by the number of infected animals and the performance at the population level. RESULTS: The model is applied to a particular set of parameters and different combinations of values. Given these imputed values, it is shown that higher levels of individual tolerance should be more effective than increased levels of resistance in commercial populations. As a practical example, a method is proposed to measure levels of animal tolerance to bovine mastitis. CONCLUSIONS: The model provides a general framework and some tools to maximize health and performances of a population under infection. Limits and assumptions of the model are clearly identified so it can be improved for different epidemiological settings.
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spelling pubmed-30661222011-03-30 Effectiveness analysis of resistance and tolerance to infection Detilleux, Johann C Genet Sel Evol Research BACKGROUND: Tolerance and resistance provide animals with two distinct strategies to fight infectious pathogens and may exhibit different evolutionary dynamics. However, few studies have investigated these mechanisms in the case of animal diseases under commercial constraints. METHODS: The paper proposes a method to simultaneously describe (1) the dynamics of transmission of a contagious pathogen between animals, (2) the growth and death of the pathogen within infected hosts and (3) the effects on their performances. The effectiveness of increasing individual levels of tolerance and resistance is evaluated by the number of infected animals and the performance at the population level. RESULTS: The model is applied to a particular set of parameters and different combinations of values. Given these imputed values, it is shown that higher levels of individual tolerance should be more effective than increased levels of resistance in commercial populations. As a practical example, a method is proposed to measure levels of animal tolerance to bovine mastitis. CONCLUSIONS: The model provides a general framework and some tools to maximize health and performances of a population under infection. Limits and assumptions of the model are clearly identified so it can be improved for different epidemiological settings. BioMed Central 2011-03-01 /pmc/articles/PMC3066122/ /pubmed/21362170 http://dx.doi.org/10.1186/1297-9686-43-9 Text en Copyright ©2011 Detilleux; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Detilleux, Johann C
Effectiveness analysis of resistance and tolerance to infection
title Effectiveness analysis of resistance and tolerance to infection
title_full Effectiveness analysis of resistance and tolerance to infection
title_fullStr Effectiveness analysis of resistance and tolerance to infection
title_full_unstemmed Effectiveness analysis of resistance and tolerance to infection
title_short Effectiveness analysis of resistance and tolerance to infection
title_sort effectiveness analysis of resistance and tolerance to infection
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3066122/
https://www.ncbi.nlm.nih.gov/pubmed/21362170
http://dx.doi.org/10.1186/1297-9686-43-9
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