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Enzymatic Blockade of the Ubiquitin-Proteasome Pathway

Ubiquitin-dependent processes control much of cellular physiology. We show that expression of a highly active, Epstein-Barr virus-derived deubiquitylating enzyme (EBV-DUB) blocks proteasomal degradation of cytosolic and ER-derived proteins by preemptive removal of ubiquitin from proteasome substrate...

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Detalles Bibliográficos
Autores principales:	Ernst, Robert, Claessen, Jasper H. L., Mueller, Britta, Sanyal, Sumana, Spooner, Eric, van der Veen, Annemarthe G., Kirak, Oktay, Schlieker, Christian D., Weihofen, Wilhelm A., Ploegh, Hidde L.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3066133/ https://www.ncbi.nlm.nih.gov/pubmed/21468303 http://dx.doi.org/10.1371/journal.pbio.1000605

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