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Transient Receptor Potential Channel Polymorphisms Are Associated with the Somatosensory Function in Neuropathic Pain Patients

Transient receptor potential channels are important mediators of thermal and mechanical stimuli and play an important role in neuropathic pain. The contribution of hereditary variants in the genes of transient receptor potential channels to neuropathic pain is unknown. We investigated the frequency...

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Autores principales: Binder, Andreas, May, Denisa, Baron, Ralf, Maier, Christoph, Tölle, Thomas R., Treede, Rolf-Detlef, Berthele, Achim, Faltraco, Frank, Flor, Herta, Gierthmühlen, Janne, Haenisch, Sierk, Huge, Volker, Magerl, Walter, Maihöfner, Christian, Richter, Helmut, Rolke, Roman, Scherens, Andrea, Üçeyler, Nurcan, Ufer, Mike, Wasner, Gunnar, Zhu, Jihong, Cascorbi, Ingolf
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3066165/
https://www.ncbi.nlm.nih.gov/pubmed/21468319
http://dx.doi.org/10.1371/journal.pone.0017387
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author Binder, Andreas
May, Denisa
Baron, Ralf
Maier, Christoph
Tölle, Thomas R.
Treede, Rolf-Detlef
Berthele, Achim
Faltraco, Frank
Flor, Herta
Gierthmühlen, Janne
Haenisch, Sierk
Huge, Volker
Magerl, Walter
Maihöfner, Christian
Richter, Helmut
Rolke, Roman
Scherens, Andrea
Üçeyler, Nurcan
Ufer, Mike
Wasner, Gunnar
Zhu, Jihong
Cascorbi, Ingolf
author_facet Binder, Andreas
May, Denisa
Baron, Ralf
Maier, Christoph
Tölle, Thomas R.
Treede, Rolf-Detlef
Berthele, Achim
Faltraco, Frank
Flor, Herta
Gierthmühlen, Janne
Haenisch, Sierk
Huge, Volker
Magerl, Walter
Maihöfner, Christian
Richter, Helmut
Rolke, Roman
Scherens, Andrea
Üçeyler, Nurcan
Ufer, Mike
Wasner, Gunnar
Zhu, Jihong
Cascorbi, Ingolf
author_sort Binder, Andreas
collection PubMed
description Transient receptor potential channels are important mediators of thermal and mechanical stimuli and play an important role in neuropathic pain. The contribution of hereditary variants in the genes of transient receptor potential channels to neuropathic pain is unknown. We investigated the frequency of transient receptor potential ankyrin 1, transient receptor potential melastin 8 and transient receptor potential vanilloid 1 single nucleotide polymorphisms and their impact on somatosensory abnormalities in neuropathic pain patients. Within the German Research Network on Neuropathic Pain (Deutscher Forscbungsverbund Neuropathischer Schmerz) 371 neuropathic pain patients were phenotypically characterized using standardized quantitative sensory testing. Pyrosequencing was employed to determine a total of eleven single nucleotide polymorphisms in transient receptor potential channel genes of the neuropathic pain patients and a cohort of 253 German healthy volunteers. Associations of quantitative sensory testing parameters and single nucleotide polymorphisms between and within groups and subgroups, based on sensory phenotypes, were analyzed. Single nucleotide polymorphisms frequencies did not differ between both the cohorts. However, in neuropathic pain patients transient receptor potential ankyrin 1 710G>A (rs920829, E179K) was associated with the presence of paradoxical heat sensation (p = 0.03), and transient receptor potential vanilloid 1 1911A>G (rs8065080, I585V) with cold hypoalgesia (p = 0.0035). Two main subgroups characterized by preserved (1) and impaired (2) sensory function were identified. In subgroup 1 transient receptor potential vanilloid 1 1911A>G led to significantly less heat hyperalgesia, pinprick hyperalgesia and mechanical hypaesthesia (p = 0.006, p = 0.005 and p<0.001) and transient receptor potential vanilloid 1 1103C>G (rs222747, M315I) to cold hypaesthesia (p = 0.002), but there was absence of associations in subgroup 2. In this study we found no evidence that genetic variants of transient receptor potential channels are involved in the expression of neuropathic pain, but transient receptor potential channel polymorphisms contributed significantly to the somatosensory abnormalities of neuropathic pain patients.
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spelling pubmed-30661652011-04-05 Transient Receptor Potential Channel Polymorphisms Are Associated with the Somatosensory Function in Neuropathic Pain Patients Binder, Andreas May, Denisa Baron, Ralf Maier, Christoph Tölle, Thomas R. Treede, Rolf-Detlef Berthele, Achim Faltraco, Frank Flor, Herta Gierthmühlen, Janne Haenisch, Sierk Huge, Volker Magerl, Walter Maihöfner, Christian Richter, Helmut Rolke, Roman Scherens, Andrea Üçeyler, Nurcan Ufer, Mike Wasner, Gunnar Zhu, Jihong Cascorbi, Ingolf PLoS One Research Article Transient receptor potential channels are important mediators of thermal and mechanical stimuli and play an important role in neuropathic pain. The contribution of hereditary variants in the genes of transient receptor potential channels to neuropathic pain is unknown. We investigated the frequency of transient receptor potential ankyrin 1, transient receptor potential melastin 8 and transient receptor potential vanilloid 1 single nucleotide polymorphisms and their impact on somatosensory abnormalities in neuropathic pain patients. Within the German Research Network on Neuropathic Pain (Deutscher Forscbungsverbund Neuropathischer Schmerz) 371 neuropathic pain patients were phenotypically characterized using standardized quantitative sensory testing. Pyrosequencing was employed to determine a total of eleven single nucleotide polymorphisms in transient receptor potential channel genes of the neuropathic pain patients and a cohort of 253 German healthy volunteers. Associations of quantitative sensory testing parameters and single nucleotide polymorphisms between and within groups and subgroups, based on sensory phenotypes, were analyzed. Single nucleotide polymorphisms frequencies did not differ between both the cohorts. However, in neuropathic pain patients transient receptor potential ankyrin 1 710G>A (rs920829, E179K) was associated with the presence of paradoxical heat sensation (p = 0.03), and transient receptor potential vanilloid 1 1911A>G (rs8065080, I585V) with cold hypoalgesia (p = 0.0035). Two main subgroups characterized by preserved (1) and impaired (2) sensory function were identified. In subgroup 1 transient receptor potential vanilloid 1 1911A>G led to significantly less heat hyperalgesia, pinprick hyperalgesia and mechanical hypaesthesia (p = 0.006, p = 0.005 and p<0.001) and transient receptor potential vanilloid 1 1103C>G (rs222747, M315I) to cold hypaesthesia (p = 0.002), but there was absence of associations in subgroup 2. In this study we found no evidence that genetic variants of transient receptor potential channels are involved in the expression of neuropathic pain, but transient receptor potential channel polymorphisms contributed significantly to the somatosensory abnormalities of neuropathic pain patients. Public Library of Science 2011-03-29 /pmc/articles/PMC3066165/ /pubmed/21468319 http://dx.doi.org/10.1371/journal.pone.0017387 Text en Binder et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Binder, Andreas
May, Denisa
Baron, Ralf
Maier, Christoph
Tölle, Thomas R.
Treede, Rolf-Detlef
Berthele, Achim
Faltraco, Frank
Flor, Herta
Gierthmühlen, Janne
Haenisch, Sierk
Huge, Volker
Magerl, Walter
Maihöfner, Christian
Richter, Helmut
Rolke, Roman
Scherens, Andrea
Üçeyler, Nurcan
Ufer, Mike
Wasner, Gunnar
Zhu, Jihong
Cascorbi, Ingolf
Transient Receptor Potential Channel Polymorphisms Are Associated with the Somatosensory Function in Neuropathic Pain Patients
title Transient Receptor Potential Channel Polymorphisms Are Associated with the Somatosensory Function in Neuropathic Pain Patients
title_full Transient Receptor Potential Channel Polymorphisms Are Associated with the Somatosensory Function in Neuropathic Pain Patients
title_fullStr Transient Receptor Potential Channel Polymorphisms Are Associated with the Somatosensory Function in Neuropathic Pain Patients
title_full_unstemmed Transient Receptor Potential Channel Polymorphisms Are Associated with the Somatosensory Function in Neuropathic Pain Patients
title_short Transient Receptor Potential Channel Polymorphisms Are Associated with the Somatosensory Function in Neuropathic Pain Patients
title_sort transient receptor potential channel polymorphisms are associated with the somatosensory function in neuropathic pain patients
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3066165/
https://www.ncbi.nlm.nih.gov/pubmed/21468319
http://dx.doi.org/10.1371/journal.pone.0017387
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