Effects of Donepezil on Behavioral Manifestations of Thalamic Infarction: A Single-Case Observation

Objective: To examine the effect of donepezil for the treatment of cognitive and behavioral disorders associated with thalamic lesions in a 45-year-old male who suffered an infarct in the left thalamus. Background: Recent studies suggest that donepezil may improve executive functions impairments due...

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Detalles Bibliográficos
Autores principales: Riveros, Rodrigo, Chabriat, Hughes, Flores, Rodrigo, Alvarez, Gonzalo, Slachevsky, Andrea
Formato: Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2011
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3066464/
https://www.ncbi.nlm.nih.gov/pubmed/21472029
http://dx.doi.org/10.3389/fneur.2011.00016
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author Riveros, Rodrigo
Chabriat, Hughes
Flores, Rodrigo
Alvarez, Gonzalo
Slachevsky, Andrea
author_facet Riveros, Rodrigo
Chabriat, Hughes
Flores, Rodrigo
Alvarez, Gonzalo
Slachevsky, Andrea
author_sort Riveros, Rodrigo
collection PubMed
description Objective: To examine the effect of donepezil for the treatment of cognitive and behavioral disorders associated with thalamic lesions in a 45-year-old male who suffered an infarct in the left thalamus. Background: Recent studies suggest that donepezil may improve executive functions impairments due to subcortical ischemic lesions. Method: The effects of donepezil were analyzed in a single-case of thalamic infarction with cognitive and behavioral alterations in an open label study. Results: Significant behavioral modifications related to improved performances in executive functions were observed with the treatment. Conclusion: The results suggest that donepezil may have significant effect on executive functions that can alter behavioral outcomes after thalamic infarctions.
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spelling pubmed-30664642011-04-06 Effects of Donepezil on Behavioral Manifestations of Thalamic Infarction: A Single-Case Observation Riveros, Rodrigo Chabriat, Hughes Flores, Rodrigo Alvarez, Gonzalo Slachevsky, Andrea Front Neurol Neuroscience Objective: To examine the effect of donepezil for the treatment of cognitive and behavioral disorders associated with thalamic lesions in a 45-year-old male who suffered an infarct in the left thalamus. Background: Recent studies suggest that donepezil may improve executive functions impairments due to subcortical ischemic lesions. Method: The effects of donepezil were analyzed in a single-case of thalamic infarction with cognitive and behavioral alterations in an open label study. Results: Significant behavioral modifications related to improved performances in executive functions were observed with the treatment. Conclusion: The results suggest that donepezil may have significant effect on executive functions that can alter behavioral outcomes after thalamic infarctions. Frontiers Research Foundation 2011-03-24 /pmc/articles/PMC3066464/ /pubmed/21472029 http://dx.doi.org/10.3389/fneur.2011.00016 Text en Copyright © 2011 Riveros, Chabriat, Flores, Alvarez and Slachevsky. http://www.frontiersin.org/licenseagreement This is an open-access article subject to an exclusive license agreement between the authors and Frontiers Media SA, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are credited.
spellingShingle Neuroscience
Riveros, Rodrigo
Chabriat, Hughes
Flores, Rodrigo
Alvarez, Gonzalo
Slachevsky, Andrea
Effects of Donepezil on Behavioral Manifestations of Thalamic Infarction: A Single-Case Observation
title Effects of Donepezil on Behavioral Manifestations of Thalamic Infarction: A Single-Case Observation
title_full Effects of Donepezil on Behavioral Manifestations of Thalamic Infarction: A Single-Case Observation
title_fullStr Effects of Donepezil on Behavioral Manifestations of Thalamic Infarction: A Single-Case Observation
title_full_unstemmed Effects of Donepezil on Behavioral Manifestations of Thalamic Infarction: A Single-Case Observation
title_short Effects of Donepezil on Behavioral Manifestations of Thalamic Infarction: A Single-Case Observation
title_sort effects of donepezil on behavioral manifestations of thalamic infarction: a single-case observation
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3066464/
https://www.ncbi.nlm.nih.gov/pubmed/21472029
http://dx.doi.org/10.3389/fneur.2011.00016
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