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Development of modified nucleosides that have supremely high anti-HIV activity and low toxicity and prevent the emergence of resistant HIV mutants
An idea to use 4′-C-substituted-2′-deoxynucleoside derivatives was proposed based on a working hypothesis to solve the problems of existing acquired immune deficiency syndrome chemotherapy (highly active antiretroviral therapy). Subsequent studies have successfully proved the validity of the idea an...
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| Formato: | Texto |
| Lenguaje: | English |
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The Japan Academy
2011
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3066546/ https://www.ncbi.nlm.nih.gov/pubmed/21422739 http://dx.doi.org/10.2183/pjab.87.53 |