Mutational analysis of the latency-associated nuclear antigen DNA-binding domain of Kaposi's sarcoma-associated herpesvirus reveals structural conservation among gammaherpesvirus origin-binding proteins

The latency-associated nuclear antigen (LANA) of Kaposi's sarcoma-associated herpesvirus functions as an origin-binding protein (OBP) and transcriptional regulator. LANA binds the terminal repeats via the C-terminal DNA-binding domain (DBD) to support latent DNA replication. To date, the struct...

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Detalles Bibliográficos
Autores principales: Han, Soo-Jin, Hu, Jianhong, Pierce, Brian, Weng, Zhiping, Renne, Rolf
Formato: Texto
Lenguaje:English
Publicado: Society for General Microbiology 2010
Materias:
Animal
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3066550/
https://www.ncbi.nlm.nih.gov/pubmed/20484563
http://dx.doi.org/10.1099/vir.0.020958-0

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