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Regulation of Serum Response Factor and Adiponectin by PPARγ Agonist Docosahexaenoic Acid
Recent studies indicate that significant health benefits involving the regulation of signaling proteins result from the consumption of omega-3 polyunsaturated fatty acids (ω-3 PUFAs). Serum response factor (SRF) is involved in transcriptional regulation of muscle growth and differentiation. SRF leve...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
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Hindawi Publishing Corporation
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3066850/ https://www.ncbi.nlm.nih.gov/pubmed/21490806 http://dx.doi.org/10.1155/2011/670479 |
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author | Johnson, Clayton Williams, Roslyn Wei, Jeanne Y. Ranganathan, Gouri |
author_facet | Johnson, Clayton Williams, Roslyn Wei, Jeanne Y. Ranganathan, Gouri |
author_sort | Johnson, Clayton |
collection | PubMed |
description | Recent studies indicate that significant health benefits involving the regulation of signaling proteins result from the consumption of omega-3 polyunsaturated fatty acids (ω-3 PUFAs). Serum response factor (SRF) is involved in transcriptional regulation of muscle growth and differentiation. SRF levels are increased in the aging heart muscle. It has not been examined whether SRF is made by adipocytes and whether SRF secretion by adipocytes is modulated by PPARγ agonist DHA. Adiponectin is made exclusively by adipocytes. We and others have previously reported that PUFAs such as DHA increase adiponectin levels and secretion in adipocytes. Here we show that DHA downregulates SRF with a simultaneous upregulation of adiponectin and that both these responses are reversible by PPARγ antagonist. Furthermore, there appears to be a direct relationship between DHA exposure and increased levels of membrane-associated high-density adiponectin, as well as lower levels of membrane-associated SRF. Thus, we find that the levels of SRF and adiponectin are inversely related in response to treatment with PPARγ agonist DHA. Decreased levels of SRF along with increase in membrane-associated adiponectin could in part mediate the health benefits of DHA. |
format | Text |
id | pubmed-3066850 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-30668502011-04-13 Regulation of Serum Response Factor and Adiponectin by PPARγ Agonist Docosahexaenoic Acid Johnson, Clayton Williams, Roslyn Wei, Jeanne Y. Ranganathan, Gouri J Lipids Research Article Recent studies indicate that significant health benefits involving the regulation of signaling proteins result from the consumption of omega-3 polyunsaturated fatty acids (ω-3 PUFAs). Serum response factor (SRF) is involved in transcriptional regulation of muscle growth and differentiation. SRF levels are increased in the aging heart muscle. It has not been examined whether SRF is made by adipocytes and whether SRF secretion by adipocytes is modulated by PPARγ agonist DHA. Adiponectin is made exclusively by adipocytes. We and others have previously reported that PUFAs such as DHA increase adiponectin levels and secretion in adipocytes. Here we show that DHA downregulates SRF with a simultaneous upregulation of adiponectin and that both these responses are reversible by PPARγ antagonist. Furthermore, there appears to be a direct relationship between DHA exposure and increased levels of membrane-associated high-density adiponectin, as well as lower levels of membrane-associated SRF. Thus, we find that the levels of SRF and adiponectin are inversely related in response to treatment with PPARγ agonist DHA. Decreased levels of SRF along with increase in membrane-associated adiponectin could in part mediate the health benefits of DHA. Hindawi Publishing Corporation 2011 2010-09-19 /pmc/articles/PMC3066850/ /pubmed/21490806 http://dx.doi.org/10.1155/2011/670479 Text en Copyright © 2011 Clayton Johnson et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Johnson, Clayton Williams, Roslyn Wei, Jeanne Y. Ranganathan, Gouri Regulation of Serum Response Factor and Adiponectin by PPARγ Agonist Docosahexaenoic Acid |
title | Regulation of Serum Response Factor and Adiponectin by PPARγ Agonist Docosahexaenoic Acid |
title_full | Regulation of Serum Response Factor and Adiponectin by PPARγ Agonist Docosahexaenoic Acid |
title_fullStr | Regulation of Serum Response Factor and Adiponectin by PPARγ Agonist Docosahexaenoic Acid |
title_full_unstemmed | Regulation of Serum Response Factor and Adiponectin by PPARγ Agonist Docosahexaenoic Acid |
title_short | Regulation of Serum Response Factor and Adiponectin by PPARγ Agonist Docosahexaenoic Acid |
title_sort | regulation of serum response factor and adiponectin by pparγ agonist docosahexaenoic acid |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3066850/ https://www.ncbi.nlm.nih.gov/pubmed/21490806 http://dx.doi.org/10.1155/2011/670479 |
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