The procoagulant effects of fine particulate matter in vivo

Inhalation of fine particulate matter (<2.5 μm; fine PM) has been shown to increase the risk for cardiovascular events. In this letter, we reappraise the role of tissue factor (TF) antigen and we also summarize changes in measured coagulation proteins in humans and rodents by other studies with f...

Descripción completa

Detalles Bibliográficos
Autores principales: Kilinç, Evren, Schulz, Holger, Kuiper, Gerhardus JAJM, Spronk, Henri MH, ten Cate, Hugo, Upadhyay, Swapna, Ganguly, Koustav, Stoeger, Tobias, Semmler-Bhenke, Manuela, Takenaka, Shinji, Kreyling, Wolfgang G, Pitz, Mike, Reitmeir, Peter, Peters, Annette, Eickelberg, Oliver, Wichmann, H Erich
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3068090/
https://www.ncbi.nlm.nih.gov/pubmed/21406084
http://dx.doi.org/10.1186/1743-8977-8-12
_version_ 1782201180838952960
author Kilinç, Evren
Schulz, Holger
Kuiper, Gerhardus JAJM
Spronk, Henri MH
ten Cate, Hugo
Upadhyay, Swapna
Ganguly, Koustav
Stoeger, Tobias
Semmler-Bhenke, Manuela
Takenaka, Shinji
Kreyling, Wolfgang G
Pitz, Mike
Reitmeir, Peter
Peters, Annette
Eickelberg, Oliver
Wichmann, H Erich
author_facet Kilinç, Evren
Schulz, Holger
Kuiper, Gerhardus JAJM
Spronk, Henri MH
ten Cate, Hugo
Upadhyay, Swapna
Ganguly, Koustav
Stoeger, Tobias
Semmler-Bhenke, Manuela
Takenaka, Shinji
Kreyling, Wolfgang G
Pitz, Mike
Reitmeir, Peter
Peters, Annette
Eickelberg, Oliver
Wichmann, H Erich
author_sort Kilinç, Evren
collection PubMed
description Inhalation of fine particulate matter (<2.5 μm; fine PM) has been shown to increase the risk for cardiovascular events. In this letter, we reappraise the role of tissue factor (TF) antigen and we also summarize changes in measured coagulation proteins in humans and rodents by other studies with fine PM. By considering all studies including ours, we conclude that monitoring the overall coagulation state by measuring capacity assays such as thrombin generation, and quantification of TF activity would be more suitable than determining single coagulation proteins (such as TF antigen) in order to better assess the systemic prothrombotic effects of fine PM.
format Text
id pubmed-3068090
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-30680902011-03-31 The procoagulant effects of fine particulate matter in vivo Kilinç, Evren Schulz, Holger Kuiper, Gerhardus JAJM Spronk, Henri MH ten Cate, Hugo Upadhyay, Swapna Ganguly, Koustav Stoeger, Tobias Semmler-Bhenke, Manuela Takenaka, Shinji Kreyling, Wolfgang G Pitz, Mike Reitmeir, Peter Peters, Annette Eickelberg, Oliver Wichmann, H Erich Part Fibre Toxicol Letter to the Editor Inhalation of fine particulate matter (<2.5 μm; fine PM) has been shown to increase the risk for cardiovascular events. In this letter, we reappraise the role of tissue factor (TF) antigen and we also summarize changes in measured coagulation proteins in humans and rodents by other studies with fine PM. By considering all studies including ours, we conclude that monitoring the overall coagulation state by measuring capacity assays such as thrombin generation, and quantification of TF activity would be more suitable than determining single coagulation proteins (such as TF antigen) in order to better assess the systemic prothrombotic effects of fine PM. BioMed Central 2011-03-15 /pmc/articles/PMC3068090/ /pubmed/21406084 http://dx.doi.org/10.1186/1743-8977-8-12 Text en Copyright ©2011 Kilinç et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Letter to the Editor
Kilinç, Evren
Schulz, Holger
Kuiper, Gerhardus JAJM
Spronk, Henri MH
ten Cate, Hugo
Upadhyay, Swapna
Ganguly, Koustav
Stoeger, Tobias
Semmler-Bhenke, Manuela
Takenaka, Shinji
Kreyling, Wolfgang G
Pitz, Mike
Reitmeir, Peter
Peters, Annette
Eickelberg, Oliver
Wichmann, H Erich
The procoagulant effects of fine particulate matter in vivo
title The procoagulant effects of fine particulate matter in vivo
title_full The procoagulant effects of fine particulate matter in vivo
title_fullStr The procoagulant effects of fine particulate matter in vivo
title_full_unstemmed The procoagulant effects of fine particulate matter in vivo
title_short The procoagulant effects of fine particulate matter in vivo
title_sort procoagulant effects of fine particulate matter in vivo
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3068090/
https://www.ncbi.nlm.nih.gov/pubmed/21406084
http://dx.doi.org/10.1186/1743-8977-8-12
work_keys_str_mv AT kilincevren theprocoagulanteffectsoffineparticulatematterinvivo
AT schulzholger theprocoagulanteffectsoffineparticulatematterinvivo
AT kuipergerhardusjajm theprocoagulanteffectsoffineparticulatematterinvivo
AT spronkhenrimh theprocoagulanteffectsoffineparticulatematterinvivo
AT tencatehugo theprocoagulanteffectsoffineparticulatematterinvivo
AT upadhyayswapna theprocoagulanteffectsoffineparticulatematterinvivo
AT gangulykoustav theprocoagulanteffectsoffineparticulatematterinvivo
AT stoegertobias theprocoagulanteffectsoffineparticulatematterinvivo
AT semmlerbhenkemanuela theprocoagulanteffectsoffineparticulatematterinvivo
AT takenakashinji theprocoagulanteffectsoffineparticulatematterinvivo
AT kreylingwolfgangg theprocoagulanteffectsoffineparticulatematterinvivo
AT pitzmike theprocoagulanteffectsoffineparticulatematterinvivo
AT reitmeirpeter theprocoagulanteffectsoffineparticulatematterinvivo
AT petersannette theprocoagulanteffectsoffineparticulatematterinvivo
AT eickelbergoliver theprocoagulanteffectsoffineparticulatematterinvivo
AT wichmannherich theprocoagulanteffectsoffineparticulatematterinvivo
AT kilincevren procoagulanteffectsoffineparticulatematterinvivo
AT schulzholger procoagulanteffectsoffineparticulatematterinvivo
AT kuipergerhardusjajm procoagulanteffectsoffineparticulatematterinvivo
AT spronkhenrimh procoagulanteffectsoffineparticulatematterinvivo
AT tencatehugo procoagulanteffectsoffineparticulatematterinvivo
AT upadhyayswapna procoagulanteffectsoffineparticulatematterinvivo
AT gangulykoustav procoagulanteffectsoffineparticulatematterinvivo
AT stoegertobias procoagulanteffectsoffineparticulatematterinvivo
AT semmlerbhenkemanuela procoagulanteffectsoffineparticulatematterinvivo
AT takenakashinji procoagulanteffectsoffineparticulatematterinvivo
AT kreylingwolfgangg procoagulanteffectsoffineparticulatematterinvivo
AT pitzmike procoagulanteffectsoffineparticulatematterinvivo
AT reitmeirpeter procoagulanteffectsoffineparticulatematterinvivo
AT petersannette procoagulanteffectsoffineparticulatematterinvivo
AT eickelbergoliver procoagulanteffectsoffineparticulatematterinvivo
AT wichmannherich procoagulanteffectsoffineparticulatematterinvivo

Ejemplares similares