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Working for Food Shifts Nocturnal Mouse Activity into the Day
Nocturnal rodents show diurnal food anticipatory activity when food access is restricted to a few hours in daytime. Timed food access also results in reduced food intake, but the role of food intake in circadian organization per se has not been described. By simulating natural food shortage in mice...
Autores principales: | , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3068156/ https://www.ncbi.nlm.nih.gov/pubmed/21479166 http://dx.doi.org/10.1371/journal.pone.0017527 |
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author | Hut, Roelof A. Pilorz, Violetta Boerema, Ate S. Strijkstra, Arjen M. Daan, Serge |
author_facet | Hut, Roelof A. Pilorz, Violetta Boerema, Ate S. Strijkstra, Arjen M. Daan, Serge |
author_sort | Hut, Roelof A. |
collection | PubMed |
description | Nocturnal rodents show diurnal food anticipatory activity when food access is restricted to a few hours in daytime. Timed food access also results in reduced food intake, but the role of food intake in circadian organization per se has not been described. By simulating natural food shortage in mice that work for food we show that reduced food intake alone shifts the activity phase from the night into the day and eventually causes nocturnal torpor (natural hypothermia). Release into continuous darkness with ad libitum food, elicits immediate reversal of activity to the previous nocturnal phase, indicating that the classical circadian pacemaker maintained its phase to the light-dark cycle. This flexibility in behavioral timing would allow mice to exploit the diurnal temporal niche while minimizing energy expenditure under poor feeding conditions in nature. This study reveals an intimate link between metabolism and mammalian circadian organization. |
format | Text |
id | pubmed-3068156 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-30681562011-04-08 Working for Food Shifts Nocturnal Mouse Activity into the Day Hut, Roelof A. Pilorz, Violetta Boerema, Ate S. Strijkstra, Arjen M. Daan, Serge PLoS One Research Article Nocturnal rodents show diurnal food anticipatory activity when food access is restricted to a few hours in daytime. Timed food access also results in reduced food intake, but the role of food intake in circadian organization per se has not been described. By simulating natural food shortage in mice that work for food we show that reduced food intake alone shifts the activity phase from the night into the day and eventually causes nocturnal torpor (natural hypothermia). Release into continuous darkness with ad libitum food, elicits immediate reversal of activity to the previous nocturnal phase, indicating that the classical circadian pacemaker maintained its phase to the light-dark cycle. This flexibility in behavioral timing would allow mice to exploit the diurnal temporal niche while minimizing energy expenditure under poor feeding conditions in nature. This study reveals an intimate link between metabolism and mammalian circadian organization. Public Library of Science 2011-03-30 /pmc/articles/PMC3068156/ /pubmed/21479166 http://dx.doi.org/10.1371/journal.pone.0017527 Text en Hut, et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Hut, Roelof A. Pilorz, Violetta Boerema, Ate S. Strijkstra, Arjen M. Daan, Serge Working for Food Shifts Nocturnal Mouse Activity into the Day |
title | Working for Food Shifts Nocturnal Mouse Activity into the Day |
title_full | Working for Food Shifts Nocturnal Mouse Activity into the Day |
title_fullStr | Working for Food Shifts Nocturnal Mouse Activity into the Day |
title_full_unstemmed | Working for Food Shifts Nocturnal Mouse Activity into the Day |
title_short | Working for Food Shifts Nocturnal Mouse Activity into the Day |
title_sort | working for food shifts nocturnal mouse activity into the day |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3068156/ https://www.ncbi.nlm.nih.gov/pubmed/21479166 http://dx.doi.org/10.1371/journal.pone.0017527 |
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