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HPV type-specific prevalence using a urine assay in unvaccinated male and female 11- to 18-year olds in Scotland

BACKGROUND: We conducted a baseline prevalence survey of unvaccinated 11- to 18-year olds to inform effectiveness studies for the new human papillomavirus (HPV) immunisation programme in Scotland. METHODS: Participants were recruited from schools and colleges and invited to provide demographic data...

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Autores principales: O'Leary, M C, Sinka, K, Robertson, C, Cuschieri, K, Lyman, R, Lacey, M, Potts, A, Cubie, H A, Donaghy, M
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3068489/
https://www.ncbi.nlm.nih.gov/pubmed/21343934
http://dx.doi.org/10.1038/bjc.2011.30
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author O'Leary, M C
Sinka, K
Robertson, C
Cuschieri, K
Lyman, R
Lacey, M
Potts, A
Cubie, H A
Donaghy, M
author_facet O'Leary, M C
Sinka, K
Robertson, C
Cuschieri, K
Lyman, R
Lacey, M
Potts, A
Cubie, H A
Donaghy, M
author_sort O'Leary, M C
collection PubMed
description BACKGROUND: We conducted a baseline prevalence survey of unvaccinated 11- to 18-year olds to inform effectiveness studies for the new human papillomavirus (HPV) immunisation programme in Scotland. METHODS: Participants were recruited from schools and colleges and invited to provide demographic data and an anonymous urine sample for type-specific HPV testing. RESULTS: Among females aged 11–14 years, the weighted prevalence was 1.1% overall; 0.9% for high-risk types and no infections were associated with types 16 and 18. Among 15- to 18-year old females, the weighted prevalence was 15.2% overall; 12.6% for high-risk types and 6.5% for types 16 and 18. Among females aged 16–18 years, infection was more frequently associated with attending college and rural schools, and showed a trend towards increasing prevalence with increasing social deprivation (P=0.045). Among males aged 11–14 years, the weighted prevalence was 1.4% overall; 1.0% for high-risk types and 0.7% for types 16 and 18. Among 15- to 18-year old males, the weighted prevalence was 3.9% overall; 2.4% for high-risk types and 0.7% for types 16 and 18. CONCLUSIONS: Human Papillomavirus prevalence is low among 11- to 14-year olds, which includes the age group targeted for routine vaccination. The prevalence in males and correlation with deprivation require further investigation.
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spelling pubmed-30684892012-03-29 HPV type-specific prevalence using a urine assay in unvaccinated male and female 11- to 18-year olds in Scotland O'Leary, M C Sinka, K Robertson, C Cuschieri, K Lyman, R Lacey, M Potts, A Cubie, H A Donaghy, M Br J Cancer Epidemiology BACKGROUND: We conducted a baseline prevalence survey of unvaccinated 11- to 18-year olds to inform effectiveness studies for the new human papillomavirus (HPV) immunisation programme in Scotland. METHODS: Participants were recruited from schools and colleges and invited to provide demographic data and an anonymous urine sample for type-specific HPV testing. RESULTS: Among females aged 11–14 years, the weighted prevalence was 1.1% overall; 0.9% for high-risk types and no infections were associated with types 16 and 18. Among 15- to 18-year old females, the weighted prevalence was 15.2% overall; 12.6% for high-risk types and 6.5% for types 16 and 18. Among females aged 16–18 years, infection was more frequently associated with attending college and rural schools, and showed a trend towards increasing prevalence with increasing social deprivation (P=0.045). Among males aged 11–14 years, the weighted prevalence was 1.4% overall; 1.0% for high-risk types and 0.7% for types 16 and 18. Among 15- to 18-year old males, the weighted prevalence was 3.9% overall; 2.4% for high-risk types and 0.7% for types 16 and 18. CONCLUSIONS: Human Papillomavirus prevalence is low among 11- to 14-year olds, which includes the age group targeted for routine vaccination. The prevalence in males and correlation with deprivation require further investigation. Nature Publishing Group 2011-03-29 2011-02-22 /pmc/articles/PMC3068489/ /pubmed/21343934 http://dx.doi.org/10.1038/bjc.2011.30 Text en Copyright © 2011 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Epidemiology
O'Leary, M C
Sinka, K
Robertson, C
Cuschieri, K
Lyman, R
Lacey, M
Potts, A
Cubie, H A
Donaghy, M
HPV type-specific prevalence using a urine assay in unvaccinated male and female 11- to 18-year olds in Scotland
title HPV type-specific prevalence using a urine assay in unvaccinated male and female 11- to 18-year olds in Scotland
title_full HPV type-specific prevalence using a urine assay in unvaccinated male and female 11- to 18-year olds in Scotland
title_fullStr HPV type-specific prevalence using a urine assay in unvaccinated male and female 11- to 18-year olds in Scotland
title_full_unstemmed HPV type-specific prevalence using a urine assay in unvaccinated male and female 11- to 18-year olds in Scotland
title_short HPV type-specific prevalence using a urine assay in unvaccinated male and female 11- to 18-year olds in Scotland
title_sort hpv type-specific prevalence using a urine assay in unvaccinated male and female 11- to 18-year olds in scotland
topic Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3068489/
https://www.ncbi.nlm.nih.gov/pubmed/21343934
http://dx.doi.org/10.1038/bjc.2011.30
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