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Factor inhibiting HIF (FIH-1) promotes renal cancer cell survival by protecting cells from HIF-1α-mediated apoptosis

BACKGROUND: Clear cell renal cell carcinoma (CCRCC) is the commonest form of kidney cancer. Up to 91% have biallelic inactivation of VHL, resulting in stabilisation of HIF-α subunits. Factor inhibiting HIF-1 is an enzyme that hydroxylates HIF-α subunits and prevents recruitment of the co-activator C...

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Detalles Bibliográficos
Autores principales:	Khan, M N, Bhattacharyya, T, Andrikopoulos, P, Esteban, M A, Barod, R, Connor, T, Ashcroft, M, Maxwell, P H, Kiriakidis, S
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2011
Materias:	Molecular Diagnostics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3068507/ https://www.ncbi.nlm.nih.gov/pubmed/21386837 http://dx.doi.org/10.1038/bjc.2011.73

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