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Epidemiology, survival, and costs of localized gastrointestinal stromal tumors

PURPOSE: The aim of this study is to examine the epidemiologic and economic burden in surgically resected localized gastrointestinal stromal tumor (GIST) patients versus age- and gender-matched controls. METHOD: Two data sources were used to conduct a series of complementary analyses. First, the Sur...

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Autores principales: Rubin, Jaime L, Sanon, Myrlene, Taylor, Douglas CA, Coombs, John, Bollu, Vamsi, Sirulnik, Leonardo
Formato: Texto
Lenguaje:English
Publicado: Dove Medical Press 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3068873/
https://www.ncbi.nlm.nih.gov/pubmed/21475624
http://dx.doi.org/10.2147/IJGM.S16090
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author Rubin, Jaime L
Sanon, Myrlene
Taylor, Douglas CA
Coombs, John
Bollu, Vamsi
Sirulnik, Leonardo
author_facet Rubin, Jaime L
Sanon, Myrlene
Taylor, Douglas CA
Coombs, John
Bollu, Vamsi
Sirulnik, Leonardo
author_sort Rubin, Jaime L
collection PubMed
description PURPOSE: The aim of this study is to examine the epidemiologic and economic burden in surgically resected localized gastrointestinal stromal tumor (GIST) patients versus age- and gender-matched controls. METHOD: Two data sources were used to conduct a series of complementary analyses. First, the Surveillance, Epidemiology, and End Results (SEER) cancer registry was used to identify diagnosed GIST patients from 1993 to 2002 and determine incidence, prevalence, and 3-year survival. Second, using the SEER–Medicare linked database, a matched case-control analysis was conducted to determine resource utilization, GIST recurrence, and costs. Because GIST recurrence is not explicitly defined in the database, patterns in resource use were used to identify probable recurrence. Kaplan–Meier Sample Average (KMSA) Estimator technique was used to estimate costs of GIST and recurrence. RESULTS: SEER registry results show over the 10-year time horizon average annual GIST incidence was 0.32 per 100,000 persons in the United States, 15-year limited-duration prevalence was 1.62 per 100,000 persons, and 3-year survival was 73%. A total of 292 GIST patients were included in the SEER–Medicare analyses; 35 were identified with probable recurrence. GIST patients had increased risk of mortality (hazard ratio: 1.23; 95% confidence intervals: 0.94–1.61) compared to controls. Median recurrence-free and postrecurrence survival was 45 and 46 months, respectively. GIST patients incurred significantly higher medical care costs in the first year after initial resection, with $23,221 attributable to GIST. GIST recurrence costs totaled $101,700 over 5 years after initial resection. CONCLUSIONS: GIST is associated with substantial medical care costs, estimated recurrence costs more than $100,000; treatments that delay or reduce recurrence could substantially reduce the burden of GIST.
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spelling pubmed-30688732011-04-07 Epidemiology, survival, and costs of localized gastrointestinal stromal tumors Rubin, Jaime L Sanon, Myrlene Taylor, Douglas CA Coombs, John Bollu, Vamsi Sirulnik, Leonardo Int J Gen Med Original Research PURPOSE: The aim of this study is to examine the epidemiologic and economic burden in surgically resected localized gastrointestinal stromal tumor (GIST) patients versus age- and gender-matched controls. METHOD: Two data sources were used to conduct a series of complementary analyses. First, the Surveillance, Epidemiology, and End Results (SEER) cancer registry was used to identify diagnosed GIST patients from 1993 to 2002 and determine incidence, prevalence, and 3-year survival. Second, using the SEER–Medicare linked database, a matched case-control analysis was conducted to determine resource utilization, GIST recurrence, and costs. Because GIST recurrence is not explicitly defined in the database, patterns in resource use were used to identify probable recurrence. Kaplan–Meier Sample Average (KMSA) Estimator technique was used to estimate costs of GIST and recurrence. RESULTS: SEER registry results show over the 10-year time horizon average annual GIST incidence was 0.32 per 100,000 persons in the United States, 15-year limited-duration prevalence was 1.62 per 100,000 persons, and 3-year survival was 73%. A total of 292 GIST patients were included in the SEER–Medicare analyses; 35 were identified with probable recurrence. GIST patients had increased risk of mortality (hazard ratio: 1.23; 95% confidence intervals: 0.94–1.61) compared to controls. Median recurrence-free and postrecurrence survival was 45 and 46 months, respectively. GIST patients incurred significantly higher medical care costs in the first year after initial resection, with $23,221 attributable to GIST. GIST recurrence costs totaled $101,700 over 5 years after initial resection. CONCLUSIONS: GIST is associated with substantial medical care costs, estimated recurrence costs more than $100,000; treatments that delay or reduce recurrence could substantially reduce the burden of GIST. Dove Medical Press 2011-02-14 /pmc/articles/PMC3068873/ /pubmed/21475624 http://dx.doi.org/10.2147/IJGM.S16090 Text en © 2011 Rubin et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.
spellingShingle Original Research
Rubin, Jaime L
Sanon, Myrlene
Taylor, Douglas CA
Coombs, John
Bollu, Vamsi
Sirulnik, Leonardo
Epidemiology, survival, and costs of localized gastrointestinal stromal tumors
title Epidemiology, survival, and costs of localized gastrointestinal stromal tumors
title_full Epidemiology, survival, and costs of localized gastrointestinal stromal tumors
title_fullStr Epidemiology, survival, and costs of localized gastrointestinal stromal tumors
title_full_unstemmed Epidemiology, survival, and costs of localized gastrointestinal stromal tumors
title_short Epidemiology, survival, and costs of localized gastrointestinal stromal tumors
title_sort epidemiology, survival, and costs of localized gastrointestinal stromal tumors
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3068873/
https://www.ncbi.nlm.nih.gov/pubmed/21475624
http://dx.doi.org/10.2147/IJGM.S16090
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