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A microarray analysis of full depth knee cartilage of ovariectomized rats
BACKGROUND: This short communication focuses the on articular cartilage and the subchondral bone, both of which play important roles in the development of osteoarthritis (OA). There are indications that estrogen-deficiency, as the post-menopausal state, accelerate the development of OA. FINDINGS: We...
Autores principales: | , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3068969/ https://www.ncbi.nlm.nih.gov/pubmed/21406075 http://dx.doi.org/10.1186/1756-0500-4-63 |
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author | Bay-Jensen, Anne C Nielsen, Rasmus H Segovia-Silvestre, Toni Azria, Moïse Staedtler, Frank Letzkus, Martin Hartmann, Nicole Brachat, Arndt H Karsdal, Morten A |
author_facet | Bay-Jensen, Anne C Nielsen, Rasmus H Segovia-Silvestre, Toni Azria, Moïse Staedtler, Frank Letzkus, Martin Hartmann, Nicole Brachat, Arndt H Karsdal, Morten A |
author_sort | Bay-Jensen, Anne C |
collection | PubMed |
description | BACKGROUND: This short communication focuses the on articular cartilage and the subchondral bone, both of which play important roles in the development of osteoarthritis (OA). There are indications that estrogen-deficiency, as the post-menopausal state, accelerate the development of OA. FINDINGS: We investigated, which extracellular matrix (ECM) protein, proteases and different pro-inflammatory factors was up- or down-regulated in the knee joint tissue in response to estrogen-deficiency in rats induced by ovariectomy. These data support previous findings that several metalloproteinases (MMPs) and cysteine proteases are co-regulated with numerous collagens and proteoglycans that are important for cartilage integrity. Furthermore quite a few pro-inflammatory cytokines were regulated by estrogen deprivation. CONCLUSION: We found multiple genes where regulated in the joint by estrogen-deficiency, many of which correspond well with our current knowledge of the pathogenesis of OA. It supports that estrogen-deficiency (e.g. OVX) may accelerate joint deterioration. However, there are also data that draw attention the need for better understanding of the synergy between proteases and tissue turnover. |
format | Text |
id | pubmed-3068969 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-30689692011-04-01 A microarray analysis of full depth knee cartilage of ovariectomized rats Bay-Jensen, Anne C Nielsen, Rasmus H Segovia-Silvestre, Toni Azria, Moïse Staedtler, Frank Letzkus, Martin Hartmann, Nicole Brachat, Arndt H Karsdal, Morten A BMC Res Notes Short Report BACKGROUND: This short communication focuses the on articular cartilage and the subchondral bone, both of which play important roles in the development of osteoarthritis (OA). There are indications that estrogen-deficiency, as the post-menopausal state, accelerate the development of OA. FINDINGS: We investigated, which extracellular matrix (ECM) protein, proteases and different pro-inflammatory factors was up- or down-regulated in the knee joint tissue in response to estrogen-deficiency in rats induced by ovariectomy. These data support previous findings that several metalloproteinases (MMPs) and cysteine proteases are co-regulated with numerous collagens and proteoglycans that are important for cartilage integrity. Furthermore quite a few pro-inflammatory cytokines were regulated by estrogen deprivation. CONCLUSION: We found multiple genes where regulated in the joint by estrogen-deficiency, many of which correspond well with our current knowledge of the pathogenesis of OA. It supports that estrogen-deficiency (e.g. OVX) may accelerate joint deterioration. However, there are also data that draw attention the need for better understanding of the synergy between proteases and tissue turnover. BioMed Central 2011-03-15 /pmc/articles/PMC3068969/ /pubmed/21406075 http://dx.doi.org/10.1186/1756-0500-4-63 Text en Copyright ©2010 Bay-Jensen et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Short Report Bay-Jensen, Anne C Nielsen, Rasmus H Segovia-Silvestre, Toni Azria, Moïse Staedtler, Frank Letzkus, Martin Hartmann, Nicole Brachat, Arndt H Karsdal, Morten A A microarray analysis of full depth knee cartilage of ovariectomized rats |
title | A microarray analysis of full depth knee cartilage of ovariectomized rats |
title_full | A microarray analysis of full depth knee cartilage of ovariectomized rats |
title_fullStr | A microarray analysis of full depth knee cartilage of ovariectomized rats |
title_full_unstemmed | A microarray analysis of full depth knee cartilage of ovariectomized rats |
title_short | A microarray analysis of full depth knee cartilage of ovariectomized rats |
title_sort | microarray analysis of full depth knee cartilage of ovariectomized rats |
topic | Short Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3068969/ https://www.ncbi.nlm.nih.gov/pubmed/21406075 http://dx.doi.org/10.1186/1756-0500-4-63 |
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