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A microarray analysis of full depth knee cartilage of ovariectomized rats

BACKGROUND: This short communication focuses the on articular cartilage and the subchondral bone, both of which play important roles in the development of osteoarthritis (OA). There are indications that estrogen-deficiency, as the post-menopausal state, accelerate the development of OA. FINDINGS: We...

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Autores principales: Bay-Jensen, Anne C, Nielsen, Rasmus H, Segovia-Silvestre, Toni, Azria, Moïse, Staedtler, Frank, Letzkus, Martin, Hartmann, Nicole, Brachat, Arndt H, Karsdal, Morten A
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3068969/
https://www.ncbi.nlm.nih.gov/pubmed/21406075
http://dx.doi.org/10.1186/1756-0500-4-63
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author Bay-Jensen, Anne C
Nielsen, Rasmus H
Segovia-Silvestre, Toni
Azria, Moïse
Staedtler, Frank
Letzkus, Martin
Hartmann, Nicole
Brachat, Arndt H
Karsdal, Morten A
author_facet Bay-Jensen, Anne C
Nielsen, Rasmus H
Segovia-Silvestre, Toni
Azria, Moïse
Staedtler, Frank
Letzkus, Martin
Hartmann, Nicole
Brachat, Arndt H
Karsdal, Morten A
author_sort Bay-Jensen, Anne C
collection PubMed
description BACKGROUND: This short communication focuses the on articular cartilage and the subchondral bone, both of which play important roles in the development of osteoarthritis (OA). There are indications that estrogen-deficiency, as the post-menopausal state, accelerate the development of OA. FINDINGS: We investigated, which extracellular matrix (ECM) protein, proteases and different pro-inflammatory factors was up- or down-regulated in the knee joint tissue in response to estrogen-deficiency in rats induced by ovariectomy. These data support previous findings that several metalloproteinases (MMPs) and cysteine proteases are co-regulated with numerous collagens and proteoglycans that are important for cartilage integrity. Furthermore quite a few pro-inflammatory cytokines were regulated by estrogen deprivation. CONCLUSION: We found multiple genes where regulated in the joint by estrogen-deficiency, many of which correspond well with our current knowledge of the pathogenesis of OA. It supports that estrogen-deficiency (e.g. OVX) may accelerate joint deterioration. However, there are also data that draw attention the need for better understanding of the synergy between proteases and tissue turnover.
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spelling pubmed-30689692011-04-01 A microarray analysis of full depth knee cartilage of ovariectomized rats Bay-Jensen, Anne C Nielsen, Rasmus H Segovia-Silvestre, Toni Azria, Moïse Staedtler, Frank Letzkus, Martin Hartmann, Nicole Brachat, Arndt H Karsdal, Morten A BMC Res Notes Short Report BACKGROUND: This short communication focuses the on articular cartilage and the subchondral bone, both of which play important roles in the development of osteoarthritis (OA). There are indications that estrogen-deficiency, as the post-menopausal state, accelerate the development of OA. FINDINGS: We investigated, which extracellular matrix (ECM) protein, proteases and different pro-inflammatory factors was up- or down-regulated in the knee joint tissue in response to estrogen-deficiency in rats induced by ovariectomy. These data support previous findings that several metalloproteinases (MMPs) and cysteine proteases are co-regulated with numerous collagens and proteoglycans that are important for cartilage integrity. Furthermore quite a few pro-inflammatory cytokines were regulated by estrogen deprivation. CONCLUSION: We found multiple genes where regulated in the joint by estrogen-deficiency, many of which correspond well with our current knowledge of the pathogenesis of OA. It supports that estrogen-deficiency (e.g. OVX) may accelerate joint deterioration. However, there are also data that draw attention the need for better understanding of the synergy between proteases and tissue turnover. BioMed Central 2011-03-15 /pmc/articles/PMC3068969/ /pubmed/21406075 http://dx.doi.org/10.1186/1756-0500-4-63 Text en Copyright ©2010 Bay-Jensen et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Report
Bay-Jensen, Anne C
Nielsen, Rasmus H
Segovia-Silvestre, Toni
Azria, Moïse
Staedtler, Frank
Letzkus, Martin
Hartmann, Nicole
Brachat, Arndt H
Karsdal, Morten A
A microarray analysis of full depth knee cartilage of ovariectomized rats
title A microarray analysis of full depth knee cartilage of ovariectomized rats
title_full A microarray analysis of full depth knee cartilage of ovariectomized rats
title_fullStr A microarray analysis of full depth knee cartilage of ovariectomized rats
title_full_unstemmed A microarray analysis of full depth knee cartilage of ovariectomized rats
title_short A microarray analysis of full depth knee cartilage of ovariectomized rats
title_sort microarray analysis of full depth knee cartilage of ovariectomized rats
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3068969/
https://www.ncbi.nlm.nih.gov/pubmed/21406075
http://dx.doi.org/10.1186/1756-0500-4-63
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