Toward forward genetic screens in malaria-causing parasites using the piggyBac transposon

The ability to analyze gene function in malaria-causing Plasmodium parasites has received a boost with a recent paper in BMC Genomics that describes a genome-wide mutagenesis system in the rodent malaria species Plasmodium berghei using the transposon piggyBac. This advance holds promise for identif...

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Detalles Bibliográficos
Autores principales: Crabb, Brendan S, de Koning-Ward, Tania F, Gilson, Paul R
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3068990/
https://www.ncbi.nlm.nih.gov/pubmed/21453557
http://dx.doi.org/10.1186/1741-7007-9-21
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author Crabb, Brendan S
de Koning-Ward, Tania F
Gilson, Paul R
author_facet Crabb, Brendan S
de Koning-Ward, Tania F
Gilson, Paul R
author_sort Crabb, Brendan S
collection PubMed
description The ability to analyze gene function in malaria-causing Plasmodium parasites has received a boost with a recent paper in BMC Genomics that describes a genome-wide mutagenesis system in the rodent malaria species Plasmodium berghei using the transposon piggyBac. This advance holds promise for identifying and validating new targets for intervention against malaria. But further improvements are still needed for the full power of genome-wide molecular genetic screens to be utilized in this organism. See research article: http://www.biomedcentral.com/1471-2164/12/155
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spelling pubmed-30689902011-04-01 Toward forward genetic screens in malaria-causing parasites using the piggyBac transposon Crabb, Brendan S de Koning-Ward, Tania F Gilson, Paul R BMC Biol Commentary The ability to analyze gene function in malaria-causing Plasmodium parasites has received a boost with a recent paper in BMC Genomics that describes a genome-wide mutagenesis system in the rodent malaria species Plasmodium berghei using the transposon piggyBac. This advance holds promise for identifying and validating new targets for intervention against malaria. But further improvements are still needed for the full power of genome-wide molecular genetic screens to be utilized in this organism. See research article: http://www.biomedcentral.com/1471-2164/12/155 BioMed Central 2011-03-31 /pmc/articles/PMC3068990/ /pubmed/21453557 http://dx.doi.org/10.1186/1741-7007-9-21 Text en Copyright ©2011 Crabb et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Commentary
Crabb, Brendan S
de Koning-Ward, Tania F
Gilson, Paul R
Toward forward genetic screens in malaria-causing parasites using the piggyBac transposon
title Toward forward genetic screens in malaria-causing parasites using the piggyBac transposon
title_full Toward forward genetic screens in malaria-causing parasites using the piggyBac transposon
title_fullStr Toward forward genetic screens in malaria-causing parasites using the piggyBac transposon
title_full_unstemmed Toward forward genetic screens in malaria-causing parasites using the piggyBac transposon
title_short Toward forward genetic screens in malaria-causing parasites using the piggyBac transposon
title_sort toward forward genetic screens in malaria-causing parasites using the piggybac transposon
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3068990/
https://www.ncbi.nlm.nih.gov/pubmed/21453557
http://dx.doi.org/10.1186/1741-7007-9-21
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