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Inhibitors of Helicobacter pylori Protease HtrA Found by ‘Virtual Ligand’ Screening Combat Bacterial Invasion of Epithelia

BACKGROUND: The human pathogen Helicobacter pylori (H. pylori) is a main cause for gastric inflammation and cancer. Increasing bacterial resistance against antibiotics demands for innovative strategies for therapeutic intervention. METHODOLOGY/PRINCIPAL FINDINGS: We present a method for structure-ba...

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Detalles Bibliográficos
Autores principales:	Löwer, Martin, Geppert, Tim, Schneider, Petra, Hoy, Benjamin, Wessler, Silja, Schneider, Gisbert
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3069028/ https://www.ncbi.nlm.nih.gov/pubmed/21483848 http://dx.doi.org/10.1371/journal.pone.0017986

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