An Anti-HIV-1 V3 Loop Antibody Fully Protects Cross-Clade and Elicits T-Cell Immunity in Macaques Mucosally Challenged with an R5 Clade C SHIV

Neutralizing antibodies have been shown to protect macaques against SHIV challenge. However, genetically diverse HIV-1 clades have evolved, and a key question left unanswered is whether neutralizing antibodies can confer cross-clade protection in vivo. The novel human monoclonal antibody HGN194 was...

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Detalles Bibliográficos
Autores principales: Watkins, Jennifer D., Siddappa, Nagadenahalli B., Lakhashe, Samir K., Humbert, Michael, Sholukh, Anton, Hemashettar, Girish, Wong, Yin Ling, Yoon, John K., Wang, Wendy, Novembre, Francis J., Villinger, Francois, Ibegbu, Chris, Patel, Kalpana, Corti, Davide, Agatic, Gloria, Vanzetta, Fabrizia, Bianchi, Siro, Heeney, Jonathan L., Sallusto, Federica, Lanzavecchia, Antonio, Ruprecht, Ruth M.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3069056/
https://www.ncbi.nlm.nih.gov/pubmed/21483815
http://dx.doi.org/10.1371/journal.pone.0018207

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