Global Gene Expression Profiling of Endothelium Exposed to Heme Reveals an Organ-Specific Induction of Cytoprotective Enzymes in Sickle Cell Disease

BACKGROUND: Sickle cell disease (SCD) is characterized by hemolysis, vaso-occlusion and ischemia reperfusion injury. These events cause endothelial dysfunction and vasculopathies in multiple systems. However, the lack of atherosclerotic lesions has led to the idea that there are adaptive mechanisms...

Descripción completa

Detalles Bibliográficos
Autores principales: Ghosh, Samit, Tan, Fang, Yu, Tianwei, Li, Yuhua, Adisa, Olufolake, Mosunjac, Mario, Ofori-Acquah, Solomon F.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3069101/
https://www.ncbi.nlm.nih.gov/pubmed/21483798
http://dx.doi.org/10.1371/journal.pone.0018399

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3069101/
https://www.ncbi.nlm.nih.gov/pubmed/21483798
http://dx.doi.org/10.1371/journal.pone.0018399

Ejemplares similares