Widespread Hypomethylation Occurs Early and Synergizes with Gene Amplification during Esophageal Carcinogenesis

Although a combination of genomic and epigenetic alterations are implicated in the multistep transformation of normal squamous esophageal epithelium to Barrett esophagus, dysplasia, and adenocarcinoma, the combinatorial effect of these changes is unknown. By integrating genome-wide DNA methylation,...

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Detalles Bibliográficos
Autores principales: Alvarez, Hector, Opalinska, Joanna, Zhou, Li, Sohal, Davendra, Fazzari, Melissa J., Yu, Yiting, Montagna, Christina, Montgomery, Elizabeth A., Canto, Marcia, Dunbar, Kerry B., Wang, Jean, Roa, Juan Carlos, Mo, Yongkai, Bhagat, Tushar, Ramesh, K. H., Cannizzaro, Linda, Mollenhauer, J., Thompson, Reid F., Suzuki, Masako, Meltzer, Stephen, Melnick, Ari, Greally, John M., Maitra, Anirban, Verma, Amit
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3069107/
https://www.ncbi.nlm.nih.gov/pubmed/21483804
http://dx.doi.org/10.1371/journal.pgen.1001356

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