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Detection of Early Sero-Conversion HIV Infection Using the INSTI(TM) HIV-1 Antibody Point-of-Care Test
We compared the INSTI(TM) HIV-1 Antibody Point-of-Care (POC) Test to laboratory-based tests for detection of early sero-conversion (i.e. acute) HIV infections. Fifty-three (53) individuals with early HIV infection, (i.e. 3(rd) generation anti-HIV EIA non-reactive or reactive, HIV-1 Western Blot non-...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
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Bentham Open
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3069355/ https://www.ncbi.nlm.nih.gov/pubmed/21464909 http://dx.doi.org/10.2174/1874613601004010176 |
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author | Cook, Darrel Gilbert, Mark DiFrancesco, Lillo Krajden, Mel |
author_facet | Cook, Darrel Gilbert, Mark DiFrancesco, Lillo Krajden, Mel |
author_sort | Cook, Darrel |
collection | PubMed |
description | We compared the INSTI(TM) HIV-1 Antibody Point-of-Care (POC) Test to laboratory-based tests for detection of early sero-conversion (i.e. acute) HIV infections. Fifty-three (53) individuals with early HIV infection, (i.e. 3(rd) generation anti-HIV EIA non-reactive or reactive, HIV-1 Western Blot non-reactive or indeterminate and HIV-1 p24 antigen reactive) were tested by INSTI(TM). The INSTI(TM) test was reactive for 34/49 (sensitivity 69.4%; 95% confidence interval 54.6-81.8%) early-infected individuals whose laboratory-based 3(rd) generation HIV EIA test was reactive. Four (4) were non-reactive by both the laboratory-based EIA and INSTI(TM )tests, but were p24 antigen reactive. The INSTI(TM )POC test performs well compared with other POC tests for the detection of early sero-conversion HIV infection, but it may miss 20% to 30% of those detected by laboratory-based 3(rd) generation anti-HIV tests. Both POC and laboratory-based anti-HIV tests will fail to detect a proportion of infected individuals in the first weeks after infection. |
format | Text |
id | pubmed-3069355 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Bentham Open |
record_format | MEDLINE/PubMed |
spelling | pubmed-30693552011-04-04 Detection of Early Sero-Conversion HIV Infection Using the INSTI(TM) HIV-1 Antibody Point-of-Care Test Cook, Darrel Gilbert, Mark DiFrancesco, Lillo Krajden, Mel Open AIDS J Article We compared the INSTI(TM) HIV-1 Antibody Point-of-Care (POC) Test to laboratory-based tests for detection of early sero-conversion (i.e. acute) HIV infections. Fifty-three (53) individuals with early HIV infection, (i.e. 3(rd) generation anti-HIV EIA non-reactive or reactive, HIV-1 Western Blot non-reactive or indeterminate and HIV-1 p24 antigen reactive) were tested by INSTI(TM). The INSTI(TM) test was reactive for 34/49 (sensitivity 69.4%; 95% confidence interval 54.6-81.8%) early-infected individuals whose laboratory-based 3(rd) generation HIV EIA test was reactive. Four (4) were non-reactive by both the laboratory-based EIA and INSTI(TM )tests, but were p24 antigen reactive. The INSTI(TM )POC test performs well compared with other POC tests for the detection of early sero-conversion HIV infection, but it may miss 20% to 30% of those detected by laboratory-based 3(rd) generation anti-HIV tests. Both POC and laboratory-based anti-HIV tests will fail to detect a proportion of infected individuals in the first weeks after infection. Bentham Open 2010-12-30 /pmc/articles/PMC3069355/ /pubmed/21464909 http://dx.doi.org/10.2174/1874613601004010176 Text en © Cook et al.; Licensee Bentham Open. http://creativecommons.org/licenses/by-nc/3.0/ This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited. |
spellingShingle | Article Cook, Darrel Gilbert, Mark DiFrancesco, Lillo Krajden, Mel Detection of Early Sero-Conversion HIV Infection Using the INSTI(TM) HIV-1 Antibody Point-of-Care Test |
title | Detection of Early Sero-Conversion HIV Infection Using the INSTI(TM) HIV-1 Antibody Point-of-Care Test |
title_full | Detection of Early Sero-Conversion HIV Infection Using the INSTI(TM) HIV-1 Antibody Point-of-Care Test |
title_fullStr | Detection of Early Sero-Conversion HIV Infection Using the INSTI(TM) HIV-1 Antibody Point-of-Care Test |
title_full_unstemmed | Detection of Early Sero-Conversion HIV Infection Using the INSTI(TM) HIV-1 Antibody Point-of-Care Test |
title_short | Detection of Early Sero-Conversion HIV Infection Using the INSTI(TM) HIV-1 Antibody Point-of-Care Test |
title_sort | detection of early sero-conversion hiv infection using the insti(tm) hiv-1 antibody point-of-care test |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3069355/ https://www.ncbi.nlm.nih.gov/pubmed/21464909 http://dx.doi.org/10.2174/1874613601004010176 |
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