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The Measurement of Language Lateralization with Functional Transcranial Doppler and Functional MRI: A Critical Evaluation
Cerebral language lateralization can be assessed in several ways. In healthy subjects, functional MRI (fMRI) during performance of a language task has evolved to be the most frequently applied method. Functional transcranial Doppler (fTCD) may provide a valid alternative, but has been used rarely. B...
Autores principales: | , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Frontiers Research Foundation
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3069547/ https://www.ncbi.nlm.nih.gov/pubmed/21483761 http://dx.doi.org/10.3389/fnhum.2011.00031 |
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author | Somers, Metten Neggers, Sebastiaan F. Diederen, Kelly M. Boks, Marco P. Kahn, René S. Sommer, Iris E. |
author_facet | Somers, Metten Neggers, Sebastiaan F. Diederen, Kelly M. Boks, Marco P. Kahn, René S. Sommer, Iris E. |
author_sort | Somers, Metten |
collection | PubMed |
description | Cerebral language lateralization can be assessed in several ways. In healthy subjects, functional MRI (fMRI) during performance of a language task has evolved to be the most frequently applied method. Functional transcranial Doppler (fTCD) may provide a valid alternative, but has been used rarely. Both techniques have their own strengths and weaknesses and as a result may be applied in different fields of research. Until now, only one relatively small study (n = 13) investigated the correlation between lateralization indices (LIs) measured by fTCD and fMRI and showed a remarkably high correlation. To further evaluate the correlation between LIs measured with fTCD and fMRI, we compared LIs of 22 healthy subjects (12 left- and 10 right-handed) using the same word generation paradigm for the fTCD as for the fMRI experiment. LIs measured with fTCD were highly but imperfectly correlated with LIs measured with fMRI (Spearman's rho = 0.75, p < 0.001). The imperfectness of the correlation can partially be explained by methodological restrictions of fMRI as well as fTCD. Our results suggest that fTCD can be a valid alternative for fMRI to measure lateralization, particularly when costs or mobility are important factors in the study design. |
format | Text |
id | pubmed-3069547 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Frontiers Research Foundation |
record_format | MEDLINE/PubMed |
spelling | pubmed-30695472011-04-11 The Measurement of Language Lateralization with Functional Transcranial Doppler and Functional MRI: A Critical Evaluation Somers, Metten Neggers, Sebastiaan F. Diederen, Kelly M. Boks, Marco P. Kahn, René S. Sommer, Iris E. Front Hum Neurosci Neuroscience Cerebral language lateralization can be assessed in several ways. In healthy subjects, functional MRI (fMRI) during performance of a language task has evolved to be the most frequently applied method. Functional transcranial Doppler (fTCD) may provide a valid alternative, but has been used rarely. Both techniques have their own strengths and weaknesses and as a result may be applied in different fields of research. Until now, only one relatively small study (n = 13) investigated the correlation between lateralization indices (LIs) measured by fTCD and fMRI and showed a remarkably high correlation. To further evaluate the correlation between LIs measured with fTCD and fMRI, we compared LIs of 22 healthy subjects (12 left- and 10 right-handed) using the same word generation paradigm for the fTCD as for the fMRI experiment. LIs measured with fTCD were highly but imperfectly correlated with LIs measured with fMRI (Spearman's rho = 0.75, p < 0.001). The imperfectness of the correlation can partially be explained by methodological restrictions of fMRI as well as fTCD. Our results suggest that fTCD can be a valid alternative for fMRI to measure lateralization, particularly when costs or mobility are important factors in the study design. Frontiers Research Foundation 2011-03-28 /pmc/articles/PMC3069547/ /pubmed/21483761 http://dx.doi.org/10.3389/fnhum.2011.00031 Text en Copyright © 2011 Somers, Neggers, Diederen, Boks, Kahn and Sommer. http://www.frontiersin.org/licenseagreement This is an open-access article subject to an exclusive license agreement between the authors and Frontiers Media SA, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are credited. |
spellingShingle | Neuroscience Somers, Metten Neggers, Sebastiaan F. Diederen, Kelly M. Boks, Marco P. Kahn, René S. Sommer, Iris E. The Measurement of Language Lateralization with Functional Transcranial Doppler and Functional MRI: A Critical Evaluation |
title | The Measurement of Language Lateralization with Functional Transcranial Doppler and Functional MRI: A Critical Evaluation |
title_full | The Measurement of Language Lateralization with Functional Transcranial Doppler and Functional MRI: A Critical Evaluation |
title_fullStr | The Measurement of Language Lateralization with Functional Transcranial Doppler and Functional MRI: A Critical Evaluation |
title_full_unstemmed | The Measurement of Language Lateralization with Functional Transcranial Doppler and Functional MRI: A Critical Evaluation |
title_short | The Measurement of Language Lateralization with Functional Transcranial Doppler and Functional MRI: A Critical Evaluation |
title_sort | measurement of language lateralization with functional transcranial doppler and functional mri: a critical evaluation |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3069547/ https://www.ncbi.nlm.nih.gov/pubmed/21483761 http://dx.doi.org/10.3389/fnhum.2011.00031 |
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