Allelic loss on chromosome band 18p11.3 occurs early and reveals heterogeneity in breast cancer progression

We examined the stage specificity and heterogeneity of 18p11 alterations in a series of tumors representing 96 microdissected samples. Significant loss of heterozygosity (LOH) (63%) was found, with 56% occurring early in ductal carcinoma in situ. Although most cases indicated LOH was clonally inheri...

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Autores principales: Kittiniyom, Kanokwan, Gorse, Karen M, Dalbegue, Fabienne, Lichy, Jack H, Taubenberger, Jeffery K, Newsham, Irene F
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2001
Materias:
Primary Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC30703/
https://www.ncbi.nlm.nih.gov/pubmed/11305954
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author Kittiniyom, Kanokwan
Gorse, Karen M
Dalbegue, Fabienne
Lichy, Jack H
Taubenberger, Jeffery K
Newsham, Irene F
author_facet Kittiniyom, Kanokwan
Gorse, Karen M
Dalbegue, Fabienne
Lichy, Jack H
Taubenberger, Jeffery K
Newsham, Irene F
author_sort Kittiniyom, Kanokwan
collection PubMed
description We examined the stage specificity and heterogeneity of 18p11 alterations in a series of tumors representing 96 microdissected samples. Significant loss of heterozygosity (LOH) (63%) was found, with 56% occurring early in ductal carcinoma in situ. Although most cases indicated LOH was clonally inherited, heterogeneity for 18p LOH occurred in 27% of tumors. When compared with other LOH data, 18p LOH was found in conjunction with allelic deletion on 3p, 9p, 17p and 17q, while 13q, 16q, and 11p were less frequently associated. These analyses suggest chromosome 18p11 alteration is a common and early event in breast disease.
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spelling pubmed-307032001-04-17 Allelic loss on chromosome band 18p11.3 occurs early and reveals heterogeneity in breast cancer progression Kittiniyom, Kanokwan Gorse, Karen M Dalbegue, Fabienne Lichy, Jack H Taubenberger, Jeffery K Newsham, Irene F Breast Cancer Res Primary Research We examined the stage specificity and heterogeneity of 18p11 alterations in a series of tumors representing 96 microdissected samples. Significant loss of heterozygosity (LOH) (63%) was found, with 56% occurring early in ductal carcinoma in situ. Although most cases indicated LOH was clonally inherited, heterogeneity for 18p LOH occurred in 27% of tumors. When compared with other LOH data, 18p LOH was found in conjunction with allelic deletion on 3p, 9p, 17p and 17q, while 13q, 16q, and 11p were less frequently associated. These analyses suggest chromosome 18p11 alteration is a common and early event in breast disease. BioMed Central 2001 2001-02-12 /pmc/articles/PMC30703/ /pubmed/11305954 Text en Copyright © 2001 Kittiniyom et al, licensee BioMed Central Ltd
spellingShingle Primary Research
Kittiniyom, Kanokwan
Gorse, Karen M
Dalbegue, Fabienne
Lichy, Jack H
Taubenberger, Jeffery K
Newsham, Irene F
Allelic loss on chromosome band 18p11.3 occurs early and reveals heterogeneity in breast cancer progression
title Allelic loss on chromosome band 18p11.3 occurs early and reveals heterogeneity in breast cancer progression
title_full Allelic loss on chromosome band 18p11.3 occurs early and reveals heterogeneity in breast cancer progression
title_fullStr Allelic loss on chromosome band 18p11.3 occurs early and reveals heterogeneity in breast cancer progression
title_full_unstemmed Allelic loss on chromosome band 18p11.3 occurs early and reveals heterogeneity in breast cancer progression
title_short Allelic loss on chromosome band 18p11.3 occurs early and reveals heterogeneity in breast cancer progression
title_sort allelic loss on chromosome band 18p11.3 occurs early and reveals heterogeneity in breast cancer progression
topic Primary Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC30703/
https://www.ncbi.nlm.nih.gov/pubmed/11305954
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