Case of relapsed AIDS-related plasmablastic lymphoma treated with autologous stem cell transplantation and highly active antiretroviral therapy

Plasmablastic lymphoma is a rare and aggressive malignancy strongly associated with HIV infection. The refractory/relapsed disease rate is high, and the survival rate is characteristically poor. There are no satisfactory salvage regimens for relapsed cases. We successfully performed autologous stem...

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Detalles Bibliográficos
Autores principales: Goto, Hiroki, Hagiwara, Shotaro, Hirai, Risen, Miyama, Takahiko, Honda, Haruhito, Tagashira, Amane, Iizuka, Toshihiko, Mochizuki, Makoto, Teruya, Katsuji, Kikuchi, Yoshimi, Oka, Shinichi, Miwa, Akiyoshi
Formato: Texto
Lenguaje:English
Publicado: PAGEPress Publications 2011
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3070448/
https://www.ncbi.nlm.nih.gov/pubmed/21464873
http://dx.doi.org/10.4081/rt.2011.e11
Descripción
Sumario:Plasmablastic lymphoma is a rare and aggressive malignancy strongly associated with HIV infection. The refractory/relapsed disease rate is high, and the survival rate is characteristically poor. There are no satisfactory salvage regimens for relapsed cases. We successfully performed autologous stem cell transplantation using a regimen consisting of MCNU (ranimustine), etoposide, cytarabine, and melphalan in a Japanese patient with relapsed AIDS-related plasmablastic lymphoma of the oral cavity. Highly active antiretroviral therapy continued during the therapy. Therapy-related toxicity was tolerable, and a total of 40 Gy of irradiation was administered after autologous stem cell transplantation. The patient has remained in complete remission for 16 months since transplantation.

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