Generation of novel cationic antimicrobial peptides from natural non-antimicrobial sequences by acid-amide substitution

BACKGROUND: Cationic antimicrobial peptides (CAMPs) are well recognized to be promising as novel antimicrobial and antitumor agents. To obtain novel skeletons of CAMPs, we propose a simple strategy using acid-amide substitution (i.e. Glu→Gln, Asp→Asn) to confer net positive charge to natural non-ant...

Descripción completa

Detalles Bibliográficos
Autores principales: Ueno, Satoshi, Minaba, Masaomi, Nishiuchi, Yuji, Taichi, Misako, Tamada, Yasushi, Yamazaki, Toshimasa, Kato, Yusuke
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3070621/
https://www.ncbi.nlm.nih.gov/pubmed/21418660
http://dx.doi.org/10.1186/1476-0711-10-11

Ejemplares similares

Ejemplares similares