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Coagulopathy as initial manifestation of concomitant celiac disease and cystic fibrosis: a case report

INTRODUCTION: Celiac disease and cystic fibrosis have many common manifestations, such as malabsorption, steatorrhea and growth failure, and were for many years recognized as one clinical entity. Since their recognition as two separate diseases, their co-existence in a patient has been described spo...

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Autores principales: Kostovski, Aco, Zdraveska, Nikolina
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3070667/
https://www.ncbi.nlm.nih.gov/pubmed/21435208
http://dx.doi.org/10.1186/1752-1947-5-116
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author Kostovski, Aco
Zdraveska, Nikolina
author_facet Kostovski, Aco
Zdraveska, Nikolina
author_sort Kostovski, Aco
collection PubMed
description INTRODUCTION: Celiac disease and cystic fibrosis have many common manifestations, such as malabsorption, steatorrhea and growth failure, and were for many years recognized as one clinical entity. Since their recognition as two separate diseases, their co-existence in a patient has been described sporadically; around 20 cases have been described in the literature. Taking into consideration the incidences of the two diseases, the chance of them occurring together is one in 2,000,000 in the general population. CASE PRESENTATION: We describe the case of a five-year-old boy of Turkish ethnicity with both celiac disease and cystic fibrosis, who presented initially with a skin hemorrhage. The diagnosis of celiac disease was made with a positive serum anti-tissue transglutaminase antibody test and the presence of HLA-DQ2 heterodimer, and confirmed on histology with small intestinal villous atrophy. A positive sweat test confirmed the diagnosis of associated cystic fibrosis. To the best of our knowledge there has been no previous report of this rare presentation of associated celiac disease and cystic fibrosis. CONCLUSION: The clinical significance of this case is the consideration of malabsorption with both celiac disease and cystic fibrosis in patients who present with unexplained coagulopathy.
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spelling pubmed-30706672011-04-05 Coagulopathy as initial manifestation of concomitant celiac disease and cystic fibrosis: a case report Kostovski, Aco Zdraveska, Nikolina J Med Case Reports Case Report INTRODUCTION: Celiac disease and cystic fibrosis have many common manifestations, such as malabsorption, steatorrhea and growth failure, and were for many years recognized as one clinical entity. Since their recognition as two separate diseases, their co-existence in a patient has been described sporadically; around 20 cases have been described in the literature. Taking into consideration the incidences of the two diseases, the chance of them occurring together is one in 2,000,000 in the general population. CASE PRESENTATION: We describe the case of a five-year-old boy of Turkish ethnicity with both celiac disease and cystic fibrosis, who presented initially with a skin hemorrhage. The diagnosis of celiac disease was made with a positive serum anti-tissue transglutaminase antibody test and the presence of HLA-DQ2 heterodimer, and confirmed on histology with small intestinal villous atrophy. A positive sweat test confirmed the diagnosis of associated cystic fibrosis. To the best of our knowledge there has been no previous report of this rare presentation of associated celiac disease and cystic fibrosis. CONCLUSION: The clinical significance of this case is the consideration of malabsorption with both celiac disease and cystic fibrosis in patients who present with unexplained coagulopathy. BioMed Central 2011-03-24 /pmc/articles/PMC3070667/ /pubmed/21435208 http://dx.doi.org/10.1186/1752-1947-5-116 Text en Copyright ©2011 Kostovski and Zdraveska; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Kostovski, Aco
Zdraveska, Nikolina
Coagulopathy as initial manifestation of concomitant celiac disease and cystic fibrosis: a case report
title Coagulopathy as initial manifestation of concomitant celiac disease and cystic fibrosis: a case report
title_full Coagulopathy as initial manifestation of concomitant celiac disease and cystic fibrosis: a case report
title_fullStr Coagulopathy as initial manifestation of concomitant celiac disease and cystic fibrosis: a case report
title_full_unstemmed Coagulopathy as initial manifestation of concomitant celiac disease and cystic fibrosis: a case report
title_short Coagulopathy as initial manifestation of concomitant celiac disease and cystic fibrosis: a case report
title_sort coagulopathy as initial manifestation of concomitant celiac disease and cystic fibrosis: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3070667/
https://www.ncbi.nlm.nih.gov/pubmed/21435208
http://dx.doi.org/10.1186/1752-1947-5-116
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