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Ginkgolide B and bilobalide block the pore of the 5-HT(3) receptor at a location that overlaps the picrotoxin binding site

Extracts from the Ginkgo biloba tree are widely used as herbal medicines, and include bilobalide (BB) and ginkgolides A and B (GA and GB). Here we examine their effects on human 5-HT(3)A and 5-HT(3)AB receptors, and compare these to the effects of the structurally related compounds picrotin (PTN) an...

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Detalles Bibliográficos
Autores principales:	Thompson, Andrew J., Jarvis, Gavin E., Duke, Rujee K., Johnston, Graham A.R., Lummis, Sarah C.R.
Formato:	Texto
Lenguaje:	English
Publicado:	Pergamon Press 2011
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3070799/ https://www.ncbi.nlm.nih.gov/pubmed/21059362 http://dx.doi.org/10.1016/j.neuropharm.2010.11.003

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