Von Willebrand factor propeptide as a marker of disease activity in systemic sclerosis (scleroderma)

In 44 consecutive patients with systemic sclerosis (SSc), plasma concentrations of von Willebrand factor (vWf) were higher than those of the vWf propeptide, but the propeptide showed less variability within patient subgroups. Higher values of the propeptide were observed in patients with early pulmo...

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Detalles Bibliográficos
Autores principales: Scheja, Agneta, Åkesson, Anita, Geborek, Pierre, Wildt, Marie, Wollheim, Claes B, Wollheim, Frank A, Vischer, Ulrich M
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2001
Materias:
Primary Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC30710/
https://www.ncbi.nlm.nih.gov/pubmed/11299058
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author Scheja, Agneta
Åkesson, Anita
Geborek, Pierre
Wildt, Marie
Wollheim, Claes B
Wollheim, Frank A
Vischer, Ulrich M
author_facet Scheja, Agneta
Åkesson, Anita
Geborek, Pierre
Wildt, Marie
Wollheim, Claes B
Wollheim, Frank A
Vischer, Ulrich M
author_sort Scheja, Agneta
collection PubMed
description In 44 consecutive patients with systemic sclerosis (SSc), plasma concentrations of von Willebrand factor (vWf) were higher than those of the vWf propeptide, but the propeptide showed less variability within patient subgroups. Higher values of the propeptide were observed in patients with early pulmonary involvement. A closer correlation of the propeptide than of vWf to biochemical markers of activity was also evident. Our results suggest that the propeptide, despite a shorter circulating half-time and lower plasma concentrations than vWf, is more useful in the assessment of disease activity in SSc.
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spelling pubmed-307102001-04-17 Von Willebrand factor propeptide as a marker of disease activity in systemic sclerosis (scleroderma) Scheja, Agneta Åkesson, Anita Geborek, Pierre Wildt, Marie Wollheim, Claes B Wollheim, Frank A Vischer, Ulrich M Arthritis Res Primary Research In 44 consecutive patients with systemic sclerosis (SSc), plasma concentrations of von Willebrand factor (vWf) were higher than those of the vWf propeptide, but the propeptide showed less variability within patient subgroups. Higher values of the propeptide were observed in patients with early pulmonary involvement. A closer correlation of the propeptide than of vWf to biochemical markers of activity was also evident. Our results suggest that the propeptide, despite a shorter circulating half-time and lower plasma concentrations than vWf, is more useful in the assessment of disease activity in SSc. BioMed Central 2001 2001-02-19 /pmc/articles/PMC30710/ /pubmed/11299058 Text en Copyright © 2001 Scheja et al, licensee BioMed Central Ltd
spellingShingle Primary Research
Scheja, Agneta
Åkesson, Anita
Geborek, Pierre
Wildt, Marie
Wollheim, Claes B
Wollheim, Frank A
Vischer, Ulrich M
Von Willebrand factor propeptide as a marker of disease activity in systemic sclerosis (scleroderma)
title Von Willebrand factor propeptide as a marker of disease activity in systemic sclerosis (scleroderma)
title_full Von Willebrand factor propeptide as a marker of disease activity in systemic sclerosis (scleroderma)
title_fullStr Von Willebrand factor propeptide as a marker of disease activity in systemic sclerosis (scleroderma)
title_full_unstemmed Von Willebrand factor propeptide as a marker of disease activity in systemic sclerosis (scleroderma)
title_short Von Willebrand factor propeptide as a marker of disease activity in systemic sclerosis (scleroderma)
title_sort von willebrand factor propeptide as a marker of disease activity in systemic sclerosis (scleroderma)
topic Primary Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC30710/
https://www.ncbi.nlm.nih.gov/pubmed/11299058
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