B lymphocyte involvement in ankylosing spondylitis: the heavy chain variable segment gene repertoire of B lymphocytes from germinal center-like foci in the synovial membrane indicates antigen selection

The synovial membrane (SM) of affected joints in ankylosing spondylitis (AS) is infiltrated by germinal center-like aggregates (foci) of lymphocytes similar to rheumatoid arthritis (RA). We characterized the rearranged heavy chain variable segment (VH) genes in the SM for gene usage and the mutation...

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Detalles Bibliográficos
Autores principales: Voswinkel, Jan, Weisgerber, Kerstin, Pfreundschuh, Michael, Gause, Angela
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2001
Materias:
Primary Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC30712/
https://www.ncbi.nlm.nih.gov/pubmed/11299060

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