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The role of vitamin D in pulmonary disease: COPD, asthma, infection, and cancer

The role of vitamin D (VitD) in calcium and bone homeostasis is well described. In the last years, it has been recognized that in addition to this classical function, VitD modulates a variety of processes and regulatory systems including host defense, inflammation, immunity, and repair. VitD deficie...

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Autores principales: Herr, Christian, Greulich, Timm, Koczulla, Rembert A, Meyer, Silke, Zakharkina, Tetyana, Branscheidt, Meret, Eschmann, Rebecca, Bals, Robert
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3071319/
https://www.ncbi.nlm.nih.gov/pubmed/21418564
http://dx.doi.org/10.1186/1465-9921-12-31
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author Herr, Christian
Greulich, Timm
Koczulla, Rembert A
Meyer, Silke
Zakharkina, Tetyana
Branscheidt, Meret
Eschmann, Rebecca
Bals, Robert
author_facet Herr, Christian
Greulich, Timm
Koczulla, Rembert A
Meyer, Silke
Zakharkina, Tetyana
Branscheidt, Meret
Eschmann, Rebecca
Bals, Robert
author_sort Herr, Christian
collection PubMed
description The role of vitamin D (VitD) in calcium and bone homeostasis is well described. In the last years, it has been recognized that in addition to this classical function, VitD modulates a variety of processes and regulatory systems including host defense, inflammation, immunity, and repair. VitD deficiency appears to be frequent in industrialized countries. Especially patients with lung diseases have often low VitD serum levels. Epidemiological data indicate that low levels of serum VitD is associated with impaired pulmonary function, increased incidence of inflammatory, infectious or neoplastic diseases. Several lung diseases, all inflammatory in nature, may be related to activities of VitD including asthma, COPD and cancer. The exact mechanisms underlying these data are unknown, however, VitD appears to impact on the function of inflammatory and structural cells, including dendritic cells, lymphocytes, monocytes, and epithelial cells. This review summarizes the knowledge on the classical and newly discovered functions of VitD, the molecular and cellular mechanism of action and the available data on the relationship between lung disease and VitD status.
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spelling pubmed-30713192011-04-06 The role of vitamin D in pulmonary disease: COPD, asthma, infection, and cancer Herr, Christian Greulich, Timm Koczulla, Rembert A Meyer, Silke Zakharkina, Tetyana Branscheidt, Meret Eschmann, Rebecca Bals, Robert Respir Res Review The role of vitamin D (VitD) in calcium and bone homeostasis is well described. In the last years, it has been recognized that in addition to this classical function, VitD modulates a variety of processes and regulatory systems including host defense, inflammation, immunity, and repair. VitD deficiency appears to be frequent in industrialized countries. Especially patients with lung diseases have often low VitD serum levels. Epidemiological data indicate that low levels of serum VitD is associated with impaired pulmonary function, increased incidence of inflammatory, infectious or neoplastic diseases. Several lung diseases, all inflammatory in nature, may be related to activities of VitD including asthma, COPD and cancer. The exact mechanisms underlying these data are unknown, however, VitD appears to impact on the function of inflammatory and structural cells, including dendritic cells, lymphocytes, monocytes, and epithelial cells. This review summarizes the knowledge on the classical and newly discovered functions of VitD, the molecular and cellular mechanism of action and the available data on the relationship between lung disease and VitD status. BioMed Central 2011 2011-03-18 /pmc/articles/PMC3071319/ /pubmed/21418564 http://dx.doi.org/10.1186/1465-9921-12-31 Text en Copyright ©2011 Herr et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Herr, Christian
Greulich, Timm
Koczulla, Rembert A
Meyer, Silke
Zakharkina, Tetyana
Branscheidt, Meret
Eschmann, Rebecca
Bals, Robert
The role of vitamin D in pulmonary disease: COPD, asthma, infection, and cancer
title The role of vitamin D in pulmonary disease: COPD, asthma, infection, and cancer
title_full The role of vitamin D in pulmonary disease: COPD, asthma, infection, and cancer
title_fullStr The role of vitamin D in pulmonary disease: COPD, asthma, infection, and cancer
title_full_unstemmed The role of vitamin D in pulmonary disease: COPD, asthma, infection, and cancer
title_short The role of vitamin D in pulmonary disease: COPD, asthma, infection, and cancer
title_sort role of vitamin d in pulmonary disease: copd, asthma, infection, and cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3071319/
https://www.ncbi.nlm.nih.gov/pubmed/21418564
http://dx.doi.org/10.1186/1465-9921-12-31
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