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Broadening the use of antiretroviral therapy: the case for feline leukemia virus
Antiretroviral drugs have saved and extended the lives of millions of individuals infected with HIV. The major classes of anti-HIV drugs include reverse transcriptase inhibitors, protease inhibitors, integrase inhibitors, and entry/fusion inhibitors. While antiretroviral drug regimens are not common...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3071348/ https://www.ncbi.nlm.nih.gov/pubmed/21479142 http://dx.doi.org/10.2147/TCRM.S17731 |
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author | Greggs, Willie M Clouser, Christine L Patterson, Steven E Mansky, Louis M |
author_facet | Greggs, Willie M Clouser, Christine L Patterson, Steven E Mansky, Louis M |
author_sort | Greggs, Willie M |
collection | PubMed |
description | Antiretroviral drugs have saved and extended the lives of millions of individuals infected with HIV. The major classes of anti-HIV drugs include reverse transcriptase inhibitors, protease inhibitors, integrase inhibitors, and entry/fusion inhibitors. While antiretroviral drug regimens are not commonly used to treat other types of retroviral infections, there are instances where there is a perceived need for re-evaluation of the benefits of antiretroviral therapy. One case in point is that of feline leukemia virus (FeLV), an infection of companion felines. While vaccines exist to prevent FeLV infection and spread, they have not eliminated FeLV infection. For FeLV-infected felines and their human companions, antiretroviral therapy would be desirable and of practical importance if good options were available. Here, we discuss FeLV biology and current treatment options, and propose that there is a need for antiretroviral treatment options for FeLV infection. The comparative use and analysis of antiretroviral therapy can provide new insights into the mechanism of antiretroviral drug action. |
format | Text |
id | pubmed-3071348 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-30713482011-04-08 Broadening the use of antiretroviral therapy: the case for feline leukemia virus Greggs, Willie M Clouser, Christine L Patterson, Steven E Mansky, Louis M Ther Clin Risk Manag Expert Opinion Antiretroviral drugs have saved and extended the lives of millions of individuals infected with HIV. The major classes of anti-HIV drugs include reverse transcriptase inhibitors, protease inhibitors, integrase inhibitors, and entry/fusion inhibitors. While antiretroviral drug regimens are not commonly used to treat other types of retroviral infections, there are instances where there is a perceived need for re-evaluation of the benefits of antiretroviral therapy. One case in point is that of feline leukemia virus (FeLV), an infection of companion felines. While vaccines exist to prevent FeLV infection and spread, they have not eliminated FeLV infection. For FeLV-infected felines and their human companions, antiretroviral therapy would be desirable and of practical importance if good options were available. Here, we discuss FeLV biology and current treatment options, and propose that there is a need for antiretroviral treatment options for FeLV infection. The comparative use and analysis of antiretroviral therapy can provide new insights into the mechanism of antiretroviral drug action. Dove Medical Press 2011 2011-03-16 /pmc/articles/PMC3071348/ /pubmed/21479142 http://dx.doi.org/10.2147/TCRM.S17731 Text en © 2011 Greggs et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited. |
spellingShingle | Expert Opinion Greggs, Willie M Clouser, Christine L Patterson, Steven E Mansky, Louis M Broadening the use of antiretroviral therapy: the case for feline leukemia virus |
title | Broadening the use of antiretroviral therapy: the case for feline leukemia virus |
title_full | Broadening the use of antiretroviral therapy: the case for feline leukemia virus |
title_fullStr | Broadening the use of antiretroviral therapy: the case for feline leukemia virus |
title_full_unstemmed | Broadening the use of antiretroviral therapy: the case for feline leukemia virus |
title_short | Broadening the use of antiretroviral therapy: the case for feline leukemia virus |
title_sort | broadening the use of antiretroviral therapy: the case for feline leukemia virus |
topic | Expert Opinion |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3071348/ https://www.ncbi.nlm.nih.gov/pubmed/21479142 http://dx.doi.org/10.2147/TCRM.S17731 |
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