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Broadening the use of antiretroviral therapy: the case for feline leukemia virus

Antiretroviral drugs have saved and extended the lives of millions of individuals infected with HIV. The major classes of anti-HIV drugs include reverse transcriptase inhibitors, protease inhibitors, integrase inhibitors, and entry/fusion inhibitors. While antiretroviral drug regimens are not common...

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Detalles Bibliográficos
Autores principales: Greggs, Willie M, Clouser, Christine L, Patterson, Steven E, Mansky, Louis M
Formato: Texto
Lenguaje:English
Publicado: Dove Medical Press 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3071348/
https://www.ncbi.nlm.nih.gov/pubmed/21479142
http://dx.doi.org/10.2147/TCRM.S17731
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author Greggs, Willie M
Clouser, Christine L
Patterson, Steven E
Mansky, Louis M
author_facet Greggs, Willie M
Clouser, Christine L
Patterson, Steven E
Mansky, Louis M
author_sort Greggs, Willie M
collection PubMed
description Antiretroviral drugs have saved and extended the lives of millions of individuals infected with HIV. The major classes of anti-HIV drugs include reverse transcriptase inhibitors, protease inhibitors, integrase inhibitors, and entry/fusion inhibitors. While antiretroviral drug regimens are not commonly used to treat other types of retroviral infections, there are instances where there is a perceived need for re-evaluation of the benefits of antiretroviral therapy. One case in point is that of feline leukemia virus (FeLV), an infection of companion felines. While vaccines exist to prevent FeLV infection and spread, they have not eliminated FeLV infection. For FeLV-infected felines and their human companions, antiretroviral therapy would be desirable and of practical importance if good options were available. Here, we discuss FeLV biology and current treatment options, and propose that there is a need for antiretroviral treatment options for FeLV infection. The comparative use and analysis of antiretroviral therapy can provide new insights into the mechanism of antiretroviral drug action.
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spelling pubmed-30713482011-04-08 Broadening the use of antiretroviral therapy: the case for feline leukemia virus Greggs, Willie M Clouser, Christine L Patterson, Steven E Mansky, Louis M Ther Clin Risk Manag Expert Opinion Antiretroviral drugs have saved and extended the lives of millions of individuals infected with HIV. The major classes of anti-HIV drugs include reverse transcriptase inhibitors, protease inhibitors, integrase inhibitors, and entry/fusion inhibitors. While antiretroviral drug regimens are not commonly used to treat other types of retroviral infections, there are instances where there is a perceived need for re-evaluation of the benefits of antiretroviral therapy. One case in point is that of feline leukemia virus (FeLV), an infection of companion felines. While vaccines exist to prevent FeLV infection and spread, they have not eliminated FeLV infection. For FeLV-infected felines and their human companions, antiretroviral therapy would be desirable and of practical importance if good options were available. Here, we discuss FeLV biology and current treatment options, and propose that there is a need for antiretroviral treatment options for FeLV infection. The comparative use and analysis of antiretroviral therapy can provide new insights into the mechanism of antiretroviral drug action. Dove Medical Press 2011 2011-03-16 /pmc/articles/PMC3071348/ /pubmed/21479142 http://dx.doi.org/10.2147/TCRM.S17731 Text en © 2011 Greggs et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.
spellingShingle Expert Opinion
Greggs, Willie M
Clouser, Christine L
Patterson, Steven E
Mansky, Louis M
Broadening the use of antiretroviral therapy: the case for feline leukemia virus
title Broadening the use of antiretroviral therapy: the case for feline leukemia virus
title_full Broadening the use of antiretroviral therapy: the case for feline leukemia virus
title_fullStr Broadening the use of antiretroviral therapy: the case for feline leukemia virus
title_full_unstemmed Broadening the use of antiretroviral therapy: the case for feline leukemia virus
title_short Broadening the use of antiretroviral therapy: the case for feline leukemia virus
title_sort broadening the use of antiretroviral therapy: the case for feline leukemia virus
topic Expert Opinion
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3071348/
https://www.ncbi.nlm.nih.gov/pubmed/21479142
http://dx.doi.org/10.2147/TCRM.S17731
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