Cargando…
Collagenolytic Activities of the Major Secreted Cathepsin L Peptidases Involved in the Virulence of the Helminth Pathogen, Fasciola hepatica
BACKGROUND: The temporal expression and secretion of distinct members of a family of virulence-associated cathepsin L cysteine peptidases (FhCL) correlates with the entry and migration of the helminth pathogen Fasciola hepatica in the host. Thus, infective larvae traversing the gut wall secrete cath...
Autores principales: | Robinson, Mark W., Corvo, Ileana, Jones, Peter M., George, Anthony M., Padula, Matthew P., To, Joyce, Cancela, Martin, Rinaldi, Gabriel, Tort, Jose F., Roche, Leda, Dalton, John P. |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2011
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3071364/ https://www.ncbi.nlm.nih.gov/pubmed/21483711 http://dx.doi.org/10.1371/journal.pntd.0001012 |
Ejemplares similares
-
Dissecting the Active Site of the Collagenolytic Cathepsin L3 Protease of the Invasive Stage of Fasciola hepatica
por: Corvo, Ileana, et al.
Publicado: (2013) -
Evaluation of Gelatinolytic and Collagenolytic Activity of Fasciola hepatica Recombinant Cathepsin-L1
por: Mokhtarian, Kobra, et al.
Publicado: (2020) -
The Zoonotic Helminth Parasite Fasciola hepatica: Virulence-Associated Cathepsin B and Cathepsin L Cysteine Peptidases Secreted by Infective Newly Excysted Juveniles (NEJ)
por: Barbour, Tara, et al.
Publicado: (2021) -
Substrate Specificity of Cysteine Proteases Beyond the S(2) Pocket: Mutagenesis and Molecular Dynamics Investigation of Fasciola hepatica Cathepsins L
por: Corvo, Ileana, et al.
Publicado: (2018) -
Identification of Chalcones as Fasciola hepatica Cathepsin L Inhibitors Using a Comprehensive Experimental and Computational Approach
por: Ferraro, Florencia, et al.
Publicado: (2016)