The Dopamine Agonist Bromocriptine Differentially Affects Fronto-Striatal Functional Connectivity During Working Memory

We investigated the effect of bromocriptine, a dopamine agonist, on individual differences in behavior as well as frontal–striatal connectivity during a working memory task. After dopaminergic augmentation, frontal–striatal connectivity in low working memory capacity individuals increases, correspon...

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Autores principales: Wallace, Deanna L., Vytlacil, Jason J., Nomura, Emi M., Gibbs, Sasha E. B., D'Esposito, Mark
Formato: Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2011
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3071499/
https://www.ncbi.nlm.nih.gov/pubmed/21503140
http://dx.doi.org/10.3389/fnhum.2011.00032
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author Wallace, Deanna L.
Vytlacil, Jason J.
Nomura, Emi M.
Gibbs, Sasha E. B.
D'Esposito, Mark
author_facet Wallace, Deanna L.
Vytlacil, Jason J.
Nomura, Emi M.
Gibbs, Sasha E. B.
D'Esposito, Mark
author_sort Wallace, Deanna L.
collection PubMed
description We investigated the effect of bromocriptine, a dopamine agonist, on individual differences in behavior as well as frontal–striatal connectivity during a working memory task. After dopaminergic augmentation, frontal–striatal connectivity in low working memory capacity individuals increases, corresponding with behavioral improvement whereas decreases in connectivity in high working memory capacity individuals are associated with poorer behavioral performance. These findings corroborate an inverted U-shape response of dopamine function in behavioral performance and provide insight on the corresponding neural mechanisms.
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spelling pubmed-30714992011-04-18 The Dopamine Agonist Bromocriptine Differentially Affects Fronto-Striatal Functional Connectivity During Working Memory Wallace, Deanna L. Vytlacil, Jason J. Nomura, Emi M. Gibbs, Sasha E. B. D'Esposito, Mark Front Hum Neurosci Neuroscience We investigated the effect of bromocriptine, a dopamine agonist, on individual differences in behavior as well as frontal–striatal connectivity during a working memory task. After dopaminergic augmentation, frontal–striatal connectivity in low working memory capacity individuals increases, corresponding with behavioral improvement whereas decreases in connectivity in high working memory capacity individuals are associated with poorer behavioral performance. These findings corroborate an inverted U-shape response of dopamine function in behavioral performance and provide insight on the corresponding neural mechanisms. Frontiers Research Foundation 2011-03-31 /pmc/articles/PMC3071499/ /pubmed/21503140 http://dx.doi.org/10.3389/fnhum.2011.00032 Text en Copyright © 2011 Wallace, Vytlacil, Nomura, Gibbs and D'Esposito. http://www.frontiersin.org/licenseagreement This is an open-access article subject to a non-exclusive license between the authors and Frontiers Media SA, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and other Frontiers conditions are complied with.
spellingShingle Neuroscience
Wallace, Deanna L.
Vytlacil, Jason J.
Nomura, Emi M.
Gibbs, Sasha E. B.
D'Esposito, Mark
The Dopamine Agonist Bromocriptine Differentially Affects Fronto-Striatal Functional Connectivity During Working Memory
title The Dopamine Agonist Bromocriptine Differentially Affects Fronto-Striatal Functional Connectivity During Working Memory
title_full The Dopamine Agonist Bromocriptine Differentially Affects Fronto-Striatal Functional Connectivity During Working Memory
title_fullStr The Dopamine Agonist Bromocriptine Differentially Affects Fronto-Striatal Functional Connectivity During Working Memory
title_full_unstemmed The Dopamine Agonist Bromocriptine Differentially Affects Fronto-Striatal Functional Connectivity During Working Memory
title_short The Dopamine Agonist Bromocriptine Differentially Affects Fronto-Striatal Functional Connectivity During Working Memory
title_sort dopamine agonist bromocriptine differentially affects fronto-striatal functional connectivity during working memory
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3071499/
https://www.ncbi.nlm.nih.gov/pubmed/21503140
http://dx.doi.org/10.3389/fnhum.2011.00032
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