R5-SHIV Induces Multiple Defects in T Cell Function during Early Infection of Rhesus Macaques Including Accumulation of T Reg Cells in Lymph Nodes

BACKGROUND: HIV-1 is a pathogen that T cell responses fail to control. HIV-1gp120 is the surface viral envelope glycoprotein that interacts with CD4 T cells and mediates entry. HIV-1gp120 has been implicated in immune dysregulatory functions that may limit anti-HIV antigen-specific T cell responses....

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Detalles Bibliográficos
Autores principales: Santosuosso, Michael, Righi, Elda, Hill, E. David, Leblanc, Pierre R., Kodish, Brett, Mylvaganam, Hari N., Siddappa, Nagadenahalli B., Stevceva, Liljana, Hu, Shiu-Lok, Ghebremichael, Musie, Chenine, Agnes-L., Hovav, Avi-Hai, Ruprecht, Ruth M., Poznansky, Mark C.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3071731/
https://www.ncbi.nlm.nih.gov/pubmed/21483689
http://dx.doi.org/10.1371/journal.pone.0018465

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