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Composition and conservation of the mRNA-degrading machinery in bacteria

RNA synthesis and decay counteract each other and therefore inversely regulate gene expression in pro- and eukaryotic cells by controlling the steady-state level of individual transcripts. Genetic and biochemical data together with recent in depth annotation of bacterial genomes indicate that many c...

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Detalles Bibliográficos
Autores principales: Kaberdin, Vladimir R, Singh, Dharam, Lin-Chao, Sue
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3071783/
https://www.ncbi.nlm.nih.gov/pubmed/21418661
http://dx.doi.org/10.1186/1423-0127-18-23
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author Kaberdin, Vladimir R
Singh, Dharam
Lin-Chao, Sue
author_facet Kaberdin, Vladimir R
Singh, Dharam
Lin-Chao, Sue
author_sort Kaberdin, Vladimir R
collection PubMed
description RNA synthesis and decay counteract each other and therefore inversely regulate gene expression in pro- and eukaryotic cells by controlling the steady-state level of individual transcripts. Genetic and biochemical data together with recent in depth annotation of bacterial genomes indicate that many components of the bacterial RNA decay machinery are evolutionarily conserved and that their functional analogues exist in organisms belonging to all kingdoms of life. Here we briefly review biological functions of essential enzymes, their evolutionary conservation and multienzyme complexes that are involved in mRNA decay in Escherichia coli and discuss their conservation in evolutionarily distant bacteria.
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spelling pubmed-30717832011-04-07 Composition and conservation of the mRNA-degrading machinery in bacteria Kaberdin, Vladimir R Singh, Dharam Lin-Chao, Sue J Biomed Sci Review RNA synthesis and decay counteract each other and therefore inversely regulate gene expression in pro- and eukaryotic cells by controlling the steady-state level of individual transcripts. Genetic and biochemical data together with recent in depth annotation of bacterial genomes indicate that many components of the bacterial RNA decay machinery are evolutionarily conserved and that their functional analogues exist in organisms belonging to all kingdoms of life. Here we briefly review biological functions of essential enzymes, their evolutionary conservation and multienzyme complexes that are involved in mRNA decay in Escherichia coli and discuss their conservation in evolutionarily distant bacteria. BioMed Central 2011-03-22 /pmc/articles/PMC3071783/ /pubmed/21418661 http://dx.doi.org/10.1186/1423-0127-18-23 Text en Copyright ©2011 Kaberdin et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Kaberdin, Vladimir R
Singh, Dharam
Lin-Chao, Sue
Composition and conservation of the mRNA-degrading machinery in bacteria
title Composition and conservation of the mRNA-degrading machinery in bacteria
title_full Composition and conservation of the mRNA-degrading machinery in bacteria
title_fullStr Composition and conservation of the mRNA-degrading machinery in bacteria
title_full_unstemmed Composition and conservation of the mRNA-degrading machinery in bacteria
title_short Composition and conservation of the mRNA-degrading machinery in bacteria
title_sort composition and conservation of the mrna-degrading machinery in bacteria
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3071783/
https://www.ncbi.nlm.nih.gov/pubmed/21418661
http://dx.doi.org/10.1186/1423-0127-18-23
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