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A High-Throughput Eight-Channel Probe Head for Murine MRI at 9.4 T

Murine MRI studies are conducted on dedicated MR systems, typically equipped with ultra-high-field magnets (≥4.7 T; bore size: ∼12–25 cm), using a single transmit-receive coil (volume or surface coil in linear or quadrature mode) or a transmit-receive coil combination. Here, we report on the design...

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Autores principales: Lanz, Titus, Müller, Matthias, Barnes, Hannah, Neubauer, Stefan, Schneider, Jürgen E
Formato: Texto
Lenguaje:English
Publicado: Wiley Subscription Services, Inc., A Wiley Company 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3071940/
https://www.ncbi.nlm.nih.gov/pubmed/20572149
http://dx.doi.org/10.1002/mrm.22414
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author Lanz, Titus
Müller, Matthias
Barnes, Hannah
Neubauer, Stefan
Schneider, Jürgen E
author_facet Lanz, Titus
Müller, Matthias
Barnes, Hannah
Neubauer, Stefan
Schneider, Jürgen E
author_sort Lanz, Titus
collection PubMed
description Murine MRI studies are conducted on dedicated MR systems, typically equipped with ultra-high-field magnets (≥4.7 T; bore size: ∼12–25 cm), using a single transmit-receive coil (volume or surface coil in linear or quadrature mode) or a transmit-receive coil combination. Here, we report on the design and characterization of an eight-channel volume receive-coil array for murine MRI at 400 MHz. The array was combined with a volume-transmit coil and integrated into one probe head. Therefore, the animal handling is fully decoupled from the radiofrequency setup. Furthermore, fixed tune and match of the coils and a reduced number of connectors minimized the setup time. Optimized preamplifier design was essential for minimizing the noise coupling between the elements. A comprehensive characterization of transmit volume resonator and receive coil array is provided. The performance of the coil array is compared to a quadrature-driven birdcage coil with identical sensitive volume. It is shown that the miniature size of the elements resulted in coil noise domination and therefore reduced signal-to-noise-ratio performance in the center compared to the quadrature birdcage. However, it allowed for 3-fold accelerated imaging of mice in vivo, reducing scan time requirements and thus increasing the number of mice that can be scanned per unit of time. Magn Reson Med, 2010. © 2010 Wiley-Liss, Inc.
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spelling pubmed-30719402011-04-08 A High-Throughput Eight-Channel Probe Head for Murine MRI at 9.4 T Lanz, Titus Müller, Matthias Barnes, Hannah Neubauer, Stefan Schneider, Jürgen E Magn Reson Med Full Paper Murine MRI studies are conducted on dedicated MR systems, typically equipped with ultra-high-field magnets (≥4.7 T; bore size: ∼12–25 cm), using a single transmit-receive coil (volume or surface coil in linear or quadrature mode) or a transmit-receive coil combination. Here, we report on the design and characterization of an eight-channel volume receive-coil array for murine MRI at 400 MHz. The array was combined with a volume-transmit coil and integrated into one probe head. Therefore, the animal handling is fully decoupled from the radiofrequency setup. Furthermore, fixed tune and match of the coils and a reduced number of connectors minimized the setup time. Optimized preamplifier design was essential for minimizing the noise coupling between the elements. A comprehensive characterization of transmit volume resonator and receive coil array is provided. The performance of the coil array is compared to a quadrature-driven birdcage coil with identical sensitive volume. It is shown that the miniature size of the elements resulted in coil noise domination and therefore reduced signal-to-noise-ratio performance in the center compared to the quadrature birdcage. However, it allowed for 3-fold accelerated imaging of mice in vivo, reducing scan time requirements and thus increasing the number of mice that can be scanned per unit of time. Magn Reson Med, 2010. © 2010 Wiley-Liss, Inc. Wiley Subscription Services, Inc., A Wiley Company 2010-07 /pmc/articles/PMC3071940/ /pubmed/20572149 http://dx.doi.org/10.1002/mrm.22414 Text en Copyright © 2010 Wiley-Liss, Inc., A Wiley Company http://creativecommons.org/licenses/by/2.5/ Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation.
spellingShingle Full Paper
Lanz, Titus
Müller, Matthias
Barnes, Hannah
Neubauer, Stefan
Schneider, Jürgen E
A High-Throughput Eight-Channel Probe Head for Murine MRI at 9.4 T
title A High-Throughput Eight-Channel Probe Head for Murine MRI at 9.4 T
title_full A High-Throughput Eight-Channel Probe Head for Murine MRI at 9.4 T
title_fullStr A High-Throughput Eight-Channel Probe Head for Murine MRI at 9.4 T
title_full_unstemmed A High-Throughput Eight-Channel Probe Head for Murine MRI at 9.4 T
title_short A High-Throughput Eight-Channel Probe Head for Murine MRI at 9.4 T
title_sort high-throughput eight-channel probe head for murine mri at 9.4 t
topic Full Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3071940/
https://www.ncbi.nlm.nih.gov/pubmed/20572149
http://dx.doi.org/10.1002/mrm.22414
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