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Functional complementation between FADD and RIP1 in embryos and lymphocytes

FADD is a common adaptor shared by several death-receptors (DRs) for signaling apoptosis through recruitment and activation of caspase 81-3. DRs are essential for immune homeostasis, but dispensable during embryogenesis. Surprisingly, FADD(−/−) mice die in utero4-5 and conditional deletion of FADD l...

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Detalles Bibliográficos
Autores principales:	Zhang, Haibing, Zhou, Xiaohui, McQuade, Thomas, Li, Jinghe, Chan, Francis Ka-Ming, Zhang, Jianke
Formato:	Texto
Lenguaje:	English
Publicado:	2011
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3072026/ https://www.ncbi.nlm.nih.gov/pubmed/21368761 http://dx.doi.org/10.1038/nature09878

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