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Intestinal epithelial stem cells do not protect their genome by asymmetric chromosome segregation

The idea that stem cells of adult tissues with high turnover are protected from DNA replication-induced mutations by maintaining the same 'immortal' template DNA strands together through successive divisions has been tested in several tissues. In the epithelium of the small intestine, the...

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Detalles Bibliográficos
Autores principales: Escobar, Marion, Nicolas, Pierre, Sangar, Fatiha, Laurent-Chabalier, Sabine, Clair, Philippe, Joubert, Dominique, Jay, Philippe, Legraverend, Catherine
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3072071/
https://www.ncbi.nlm.nih.gov/pubmed/21448157
http://dx.doi.org/10.1038/ncomms1260