Characterization of single-file flow through human retinal parafoveal capillaries using an adaptive optics scanning laser ophthalmoscope

Adaptive Optics Scanning Laser Ophthalmoscopy was used to noninvasively acquire videos of single-file flow through live human retinal parafoveal capillaries. Videos were analyzed offline to investigate capillary flow dynamics. Certain capillaries accounted for a clear majority of leukocyte traffic (...

Descripción completa

Detalles Bibliográficos
Autores principales: Tam, Johnny, Tiruveedhula, Pavan, Roorda, Austin
Formato: Texto
Lenguaje:English
Publicado: Optical Society of America 2011
Materias:
Cardiovascular Applications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3072121/
https://www.ncbi.nlm.nih.gov/pubmed/21483603
http://dx.doi.org/10.1364/BOE.2.000781
_version_ 1782201511271464960
author Tam, Johnny
Tiruveedhula, Pavan
Roorda, Austin
author_facet Tam, Johnny
Tiruveedhula, Pavan
Roorda, Austin
author_sort Tam, Johnny
collection PubMed
description Adaptive Optics Scanning Laser Ophthalmoscopy was used to noninvasively acquire videos of single-file flow through live human retinal parafoveal capillaries. Videos were analyzed offline to investigate capillary flow dynamics. Certain capillaries accounted for a clear majority of leukocyte traffic (Leukocyte-Preferred-Paths, LPPs), while other capillaries primarily featured plasma gap flow (Plasma-Gap-Capillaries, PGCs). LPPs may serve as a protective mechanism to prevent inactivated leukocytes from entering exchange capillaries, and PGCs may serve as relief valves to minimize flow disruption due to the presence of a leukocyte in a neighboring LPP.
format Text
id pubmed-3072121
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher Optical Society of America
record_format MEDLINE/PubMed
spelling pubmed-30721212011-04-11 Characterization of single-file flow through human retinal parafoveal capillaries using an adaptive optics scanning laser ophthalmoscope Tam, Johnny Tiruveedhula, Pavan Roorda, Austin Biomed Opt Express Cardiovascular Applications Adaptive Optics Scanning Laser Ophthalmoscopy was used to noninvasively acquire videos of single-file flow through live human retinal parafoveal capillaries. Videos were analyzed offline to investigate capillary flow dynamics. Certain capillaries accounted for a clear majority of leukocyte traffic (Leukocyte-Preferred-Paths, LPPs), while other capillaries primarily featured plasma gap flow (Plasma-Gap-Capillaries, PGCs). LPPs may serve as a protective mechanism to prevent inactivated leukocytes from entering exchange capillaries, and PGCs may serve as relief valves to minimize flow disruption due to the presence of a leukocyte in a neighboring LPP. Optical Society of America 2011-03-02 /pmc/articles/PMC3072121/ /pubmed/21483603 http://dx.doi.org/10.1364/BOE.2.000781 Text en ©2011 Optical Society of America http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 Unported License, which permits download and redistribution, provided that the original work is properly cited. This license restricts the article from being modified or used commercially.
spellingShingle Cardiovascular Applications
Tam, Johnny
Tiruveedhula, Pavan
Roorda, Austin
Characterization of single-file flow through human retinal parafoveal capillaries using an adaptive optics scanning laser ophthalmoscope
title Characterization of single-file flow through human retinal parafoveal capillaries using an adaptive optics scanning laser ophthalmoscope
title_full Characterization of single-file flow through human retinal parafoveal capillaries using an adaptive optics scanning laser ophthalmoscope
title_fullStr Characterization of single-file flow through human retinal parafoveal capillaries using an adaptive optics scanning laser ophthalmoscope
title_full_unstemmed Characterization of single-file flow through human retinal parafoveal capillaries using an adaptive optics scanning laser ophthalmoscope
title_short Characterization of single-file flow through human retinal parafoveal capillaries using an adaptive optics scanning laser ophthalmoscope
title_sort characterization of single-file flow through human retinal parafoveal capillaries using an adaptive optics scanning laser ophthalmoscope
topic Cardiovascular Applications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3072121/
https://www.ncbi.nlm.nih.gov/pubmed/21483603
http://dx.doi.org/10.1364/BOE.2.000781
work_keys_str_mv AT tamjohnny characterizationofsinglefileflowthroughhumanretinalparafovealcapillariesusinganadaptiveopticsscanninglaserophthalmoscope
AT tiruveedhulapavan characterizationofsinglefileflowthroughhumanretinalparafovealcapillariesusinganadaptiveopticsscanninglaserophthalmoscope
AT roordaaustin characterizationofsinglefileflowthroughhumanretinalparafovealcapillariesusinganadaptiveopticsscanninglaserophthalmoscope

Ejemplares similares