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Breast cancer associated with primary hyperparathyroidism: a nested case control study
BACKGROUND: Primary hyperparathyroidism (pHPT) is associated with an increased risk of developing breast cancer, but little is known about the underlying factors. The aim of this study was to compare women with a history of pHPT and a reference population in terms of standard factors predictive of p...
Autores principales: | , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Dove Medical Press
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3072153/ https://www.ncbi.nlm.nih.gov/pubmed/21487450 http://dx.doi.org/10.2147/CLEP.S17298 |
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author | Norenstedt, Sophie Granath, Fredrik Ekbom, Anders Bergh, Jonas Lambe, Mats Adolfsson, Jan Warnberg, Fredrik Zedenius, Jan Nilsson, Inga-Lena |
author_facet | Norenstedt, Sophie Granath, Fredrik Ekbom, Anders Bergh, Jonas Lambe, Mats Adolfsson, Jan Warnberg, Fredrik Zedenius, Jan Nilsson, Inga-Lena |
author_sort | Norenstedt, Sophie |
collection | PubMed |
description | BACKGROUND: Primary hyperparathyroidism (pHPT) is associated with an increased risk of developing breast cancer, but little is known about the underlying factors. The aim of this study was to compare women with a history of pHPT and a reference population in terms of standard factors predictive of prognosis and response to therapy for breast cancer. METHODS: We analyzed data collected from the National Swedish Cancer Register and from two regional oncologic center registries. Seventy-one women with breast cancer and a history of parathyroid adenomectomy were compared with 338 matched controls with breast cancer only. Tumor size, stage, hormone receptor status, lymph node status, cause of death, and cumulative survival were analyzed. RESULTS: The mean age was 69 ± 11 years (95% confidence interval [CI]: 68–70) in both groups and the mean time interval between the parathyroid surgery and breast cancer diagnosis was 91 ± 68 months (95% CI: 72–111). There were no differences between the two groups regarding size, stage, lymph node metastases, or survival, but none of the cases with a history of pHPT were found in Stage III or IV. CONCLUSION: In conclusion, factors predictive of prognosis and response to therapy in women with a history of pHPT and breast cancer are similar to those in breast cancer patients without pHPT. |
format | Text |
id | pubmed-3072153 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-30721532011-04-12 Breast cancer associated with primary hyperparathyroidism: a nested case control study Norenstedt, Sophie Granath, Fredrik Ekbom, Anders Bergh, Jonas Lambe, Mats Adolfsson, Jan Warnberg, Fredrik Zedenius, Jan Nilsson, Inga-Lena Clin Epidemiol Original Research BACKGROUND: Primary hyperparathyroidism (pHPT) is associated with an increased risk of developing breast cancer, but little is known about the underlying factors. The aim of this study was to compare women with a history of pHPT and a reference population in terms of standard factors predictive of prognosis and response to therapy for breast cancer. METHODS: We analyzed data collected from the National Swedish Cancer Register and from two regional oncologic center registries. Seventy-one women with breast cancer and a history of parathyroid adenomectomy were compared with 338 matched controls with breast cancer only. Tumor size, stage, hormone receptor status, lymph node status, cause of death, and cumulative survival were analyzed. RESULTS: The mean age was 69 ± 11 years (95% confidence interval [CI]: 68–70) in both groups and the mean time interval between the parathyroid surgery and breast cancer diagnosis was 91 ± 68 months (95% CI: 72–111). There were no differences between the two groups regarding size, stage, lymph node metastases, or survival, but none of the cases with a history of pHPT were found in Stage III or IV. CONCLUSION: In conclusion, factors predictive of prognosis and response to therapy in women with a history of pHPT and breast cancer are similar to those in breast cancer patients without pHPT. Dove Medical Press 2011-03-25 /pmc/articles/PMC3072153/ /pubmed/21487450 http://dx.doi.org/10.2147/CLEP.S17298 Text en © 2011 Norenstedt et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited. |
spellingShingle | Original Research Norenstedt, Sophie Granath, Fredrik Ekbom, Anders Bergh, Jonas Lambe, Mats Adolfsson, Jan Warnberg, Fredrik Zedenius, Jan Nilsson, Inga-Lena Breast cancer associated with primary hyperparathyroidism: a nested case control study |
title | Breast cancer associated with primary hyperparathyroidism: a nested case control study |
title_full | Breast cancer associated with primary hyperparathyroidism: a nested case control study |
title_fullStr | Breast cancer associated with primary hyperparathyroidism: a nested case control study |
title_full_unstemmed | Breast cancer associated with primary hyperparathyroidism: a nested case control study |
title_short | Breast cancer associated with primary hyperparathyroidism: a nested case control study |
title_sort | breast cancer associated with primary hyperparathyroidism: a nested case control study |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3072153/ https://www.ncbi.nlm.nih.gov/pubmed/21487450 http://dx.doi.org/10.2147/CLEP.S17298 |
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