Cerebellar Degeneration as Presenting Symptom of Recurrent Endometrial Stromal Sarcoma with Sex-Cord Elements

We report a 66-year-old woman with slowly progressive ataxia due to cerebellar atrophy. Imaging studies revealed multiple lesions in both the lungs and dorsal subpleural space. A biopsy identified the lesions as metastases of a low-grade endometrial stromal sarcoma containing sex-cord elements. The...

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Detalles Bibliográficos
Autores principales: Gliem, Michael, Panayotopoulos, Dimitris, Feindt, Peter, Heikaus, Sebastian, Fleisch, Markus C., Seitz, Rüdiger J.
Formato: Texto
Lenguaje:English
Publicado: S. Karger AG 2011
Materias:
Published: February 2011
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3072195/
https://www.ncbi.nlm.nih.gov/pubmed/21490714
http://dx.doi.org/10.1159/000324927
Descripción
Sumario:We report a 66-year-old woman with slowly progressive ataxia due to cerebellar atrophy. Imaging studies revealed multiple lesions in both the lungs and dorsal subpleural space. A biopsy identified the lesions as metastases of a low-grade endometrial stromal sarcoma containing sex-cord elements. The histological appearance was identical to a uterine tumor the patient was treated for with hysterectomy 16 years before. The metastases were removed surgically, and after 3 months ataxia had regressed. We conclude that the presenting cerebellar degeneration in this patient resulted from the metastatic recurrence of the endometrial tumor.

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