A phase I trial to evaluate the safety and pharmacokinetics of low-dose methotrexate as an anti-malarial drug in Kenyan adult healthy volunteers

BACKGROUND: Previous investigations indicate that methotrexate, an old anticancer drug, could be used at low doses to treat malaria. A phase I evaluation was conducted to assess the safety and pharmacokinetic profile of this drug in healthy adult male Kenyan volunteers. METHODS: Twenty five healthy...

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Detalles Bibliográficos
Autores principales: Chilengi, Roma, Juma, Rashid, Abdallah, Ahmed M, Bashraheil, Mahfudh, Lodenyo, Hudson, Nyakundi, Priscilla, Anabwani, Evelyn, Salim, Amina, Mwambingu, Gabriel, Wenwa, Ednah, Jemutai, Julie, Kipkeu, Chemtai, Oyoo, George O, Muchohi, Simon N, Kokwaro, Gilbert, Niehues, Tim, Lang, Trudie, Nzila, Alexis
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3072355/
https://www.ncbi.nlm.nih.gov/pubmed/21410944
http://dx.doi.org/10.1186/1475-2875-10-63

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