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Brain Abnormalities and Glioma-Like Lesions in Mice Overexpressing the Long Isoform of PDGF-A in Astrocytic Cells

BACKGROUND: Deregulation of platelet-derived growth factor (PDGF) signaling is a hallmark of malignant glioma. Two alternatively spliced PDGF-A mRNAs have been described, corresponding to a long (L) and a short (S) isoform of PDGF-A. In contrast to PDGF-A(S), the PDGF-A(L) isoform has a lysine and a...

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Detalles Bibliográficos
Autores principales:	Nazarenko, Inga, Hedrén, Anna, Sjödin, Hanna, Orrego, Abiel, Andrae, Johanna, Afink, Gijs B., Nistér, Monica, Lindström, Mikael S.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3072383/ https://www.ncbi.nlm.nih.gov/pubmed/21490965 http://dx.doi.org/10.1371/journal.pone.0018303

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