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Efficient Silencing of Gene Expression by an ASON–Bulge–DNAzyme Complex
BACKGROUND: DNAzymes are DNA molecules that can directly cleave cognate mRNA, and have been developed to silence gene expression for research and clinical purposes. The advantage of DNAzymes over ribozymes is that they are inexpensive to produce and exhibit good stability. The “10-23 DNA enzyme” is...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2011
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3072403/ https://www.ncbi.nlm.nih.gov/pubmed/21490924 http://dx.doi.org/10.1371/journal.pone.0018629 |