Single HA2 Mutation Increases the Infectivity and Immunogenicity of a Live Attenuated H5N1 Intranasal Influenza Vaccine Candidate Lacking NS1

BACKGROUND: H5N1 influenza vaccines, including live intranasal, appear to be relatively less immunogenic compared to seasonal analogs. The main influenza virus surface glycoprotein hemagglutinin (HA) of highly pathogenic avian influenza viruses (HPAIV) was shown to be more susceptible to acidic pH t...

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Detalles Bibliográficos
Autores principales: Krenn, Brigitte M., Egorov, Andrej, Romanovskaya-Romanko, Ekaterina, Wolschek, Markus, Nakowitsch, Sabine, Ruthsatz, Tanja, Kiefmann, Bettina, Morokutti, Alexander, Humer, Johannes, Geiler, Janina, Cinatl, Jindrich, Michaelis, Martin, Wressnigg, Nina, Sturlan, Sanda, Ferko, Boris, Batishchev, Oleg V., Indenbom, Andrey V., Zhu, Rong, Kastner, Markus, Hinterdorfer, Peter, Kiselev, Oleg, Muster, Thomas, Romanova, Julia
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3072404/
https://www.ncbi.nlm.nih.gov/pubmed/21490925
http://dx.doi.org/10.1371/journal.pone.0018577

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