Two Pediatric Osteosarcoma Cases with Delayed Methotrexate Excretion: Its Clinical Course and Management

High-dose methotrexate (MTX) chemotherapy extends the duration of hospitalization and introduces the risks of serious complications related to delayed MTX excretion. The treatment of delayed MTX excretion is largely dependent on invasive measures such as hemodialysis because the clinical data regard...

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Autores principales: Lee, Kang Min, Lee, Hee Woo, Kim, Seung Yeon, Lee, Hyeon Jeong, Kim, Dong Hwan, Cho, Joongbum, Kim, Dong Ho, Lim, Jung Sub, Lee, Jin Kyung, Lee, Jun Ah
Formato: Texto
Lenguaje:English
Publicado: Korean Cancer Association 2011
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3072537/
https://www.ncbi.nlm.nih.gov/pubmed/21509165
http://dx.doi.org/10.4143/crt.2011.43.1.67
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author Lee, Kang Min
Lee, Hee Woo
Kim, Seung Yeon
Lee, Hyeon Jeong
Kim, Dong Hwan
Cho, Joongbum
Kim, Dong Ho
Lim, Jung Sub
Lee, Jin Kyung
Lee, Jun Ah
author_facet Lee, Kang Min
Lee, Hee Woo
Kim, Seung Yeon
Lee, Hyeon Jeong
Kim, Dong Hwan
Cho, Joongbum
Kim, Dong Ho
Lim, Jung Sub
Lee, Jin Kyung
Lee, Jun Ah
author_sort Lee, Kang Min
collection PubMed
description High-dose methotrexate (MTX) chemotherapy extends the duration of hospitalization and introduces the risks of serious complications related to delayed MTX excretion. The treatment of delayed MTX excretion is largely dependent on invasive measures such as hemodialysis because the clinical data regarding the efficacy or safety of carboxypetidase G(2) is limited. We report here on the cases of two pediatric osteosarcoma patients with delayed MTX excretion and who were successfully managed using supportive measures. Potential life-threatening complications were prevented by administering high doses of leucovorin.
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spelling pubmed-30725372011-04-20 Two Pediatric Osteosarcoma Cases with Delayed Methotrexate Excretion: Its Clinical Course and Management Lee, Kang Min Lee, Hee Woo Kim, Seung Yeon Lee, Hyeon Jeong Kim, Dong Hwan Cho, Joongbum Kim, Dong Ho Lim, Jung Sub Lee, Jin Kyung Lee, Jun Ah Cancer Res Treat Case Report High-dose methotrexate (MTX) chemotherapy extends the duration of hospitalization and introduces the risks of serious complications related to delayed MTX excretion. The treatment of delayed MTX excretion is largely dependent on invasive measures such as hemodialysis because the clinical data regarding the efficacy or safety of carboxypetidase G(2) is limited. We report here on the cases of two pediatric osteosarcoma patients with delayed MTX excretion and who were successfully managed using supportive measures. Potential life-threatening complications were prevented by administering high doses of leucovorin. Korean Cancer Association 2011-03 2011-03-31 /pmc/articles/PMC3072537/ /pubmed/21509165 http://dx.doi.org/10.4143/crt.2011.43.1.67 Text en Copyright © 2011 by the Korean Cancer Association http://creativecommons.org/licenses/by-nc/3.0 This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Lee, Kang Min
Lee, Hee Woo
Kim, Seung Yeon
Lee, Hyeon Jeong
Kim, Dong Hwan
Cho, Joongbum
Kim, Dong Ho
Lim, Jung Sub
Lee, Jin Kyung
Lee, Jun Ah
Two Pediatric Osteosarcoma Cases with Delayed Methotrexate Excretion: Its Clinical Course and Management
title Two Pediatric Osteosarcoma Cases with Delayed Methotrexate Excretion: Its Clinical Course and Management
title_full Two Pediatric Osteosarcoma Cases with Delayed Methotrexate Excretion: Its Clinical Course and Management
title_fullStr Two Pediatric Osteosarcoma Cases with Delayed Methotrexate Excretion: Its Clinical Course and Management
title_full_unstemmed Two Pediatric Osteosarcoma Cases with Delayed Methotrexate Excretion: Its Clinical Course and Management
title_short Two Pediatric Osteosarcoma Cases with Delayed Methotrexate Excretion: Its Clinical Course and Management
title_sort two pediatric osteosarcoma cases with delayed methotrexate excretion: its clinical course and management
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3072537/
https://www.ncbi.nlm.nih.gov/pubmed/21509165
http://dx.doi.org/10.4143/crt.2011.43.1.67
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