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Properties of Injectable Apatite-Forming Premixed Cements
Previous studies reported premixed calcium phosphate cements (CPCs) that were stable in the package and form hydroxyapatite (HA) as the product after exposure to an aqueous environment. These cements had setting times of greater than 60 min, which are too long to be useful for some clinical applicat...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
[Gaithersburg, MD] : U.S. Dept. of Commerce, National Institute of Standards and Technology
2010
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3072679/ https://www.ncbi.nlm.nih.gov/pubmed/21479133 http://dx.doi.org/10.6028/jres.115.017 |
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author | Shimada, Yashushi Chow, Laurence C. Takagi, Shozo Tagami, Junji |
author_facet | Shimada, Yashushi Chow, Laurence C. Takagi, Shozo Tagami, Junji |
author_sort | Shimada, Yashushi |
collection | PubMed |
description | Previous studies reported premixed calcium phosphate cements (CPCs) that were stable in the package and form hydroxyapatite (HA) as the product after exposure to an aqueous environment. These cements had setting times of greater than 60 min, which are too long to be useful for some clinical applications. The present study investigated properties of fast-setting HA-forming premixed CPCs that initially consisted of two separate premixed pastes: (1) finely ground (1.0 μm in median size) dicalcium phosphate anhydrous (DCPA) mixed with an aqueous NaH(2)PO(4) solution, 1.5 mol/L or 3.0 mol/L in concentration, and (2) tetracalcium phosphate consisting of combinations of particles of two different size distributions, 5 μm (TTCP5) and 17 μm (TTCP17) in median size, mixed with glycerin. Equal volume of Pastes 1 and 2 were injected with the use of atwo-barrel syringe fitted with a static mixer into sample molds. The molar Ca/P ratio of combined paste was approximately 1.5. Cements were characterized in terms of setting time (Gilmore needle), diametral tensile strength (DTS), and phase composition (powder x-ray diffraction, XRD). Setting times were found to range from (4.3 ± 0.6 to 68 ± 3) min (mean ± sd; n = 3), and 1-d and 7-d DTS values were from (0.89 ± 0.08 to 2.44 ± 0.16) MPa (mean ± sd; n = 5). Both the NaH(2)PO(4) concentration and TTCP particle size distribution had significant (p < 0.01) effects on setting time and DTS. Powder XRD analysis showed that low crystallinity HA and unreacted DCPA were present in the 1-day specimens, and the extent of HA formation increased with increasing amount of TTCP5 in the TTCP paste. Conclusion: Injectable HA-forming premixed CPCs with setting times from 4 to 70 min can be prepared by using DCPA and TTCP as the ingredients. Compared to the conventional powder liquid cements, these premixed CPCs have the advantages of being easy to use and having a range of hardening times. |
format | Text |
id | pubmed-3072679 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | [Gaithersburg, MD] : U.S. Dept. of Commerce, National Institute of Standards and Technology |
record_format | MEDLINE/PubMed |
spelling | pubmed-30726792011-04-08 Properties of Injectable Apatite-Forming Premixed Cements Shimada, Yashushi Chow, Laurence C. Takagi, Shozo Tagami, Junji J Res Natl Inst Stand Technol Article Previous studies reported premixed calcium phosphate cements (CPCs) that were stable in the package and form hydroxyapatite (HA) as the product after exposure to an aqueous environment. These cements had setting times of greater than 60 min, which are too long to be useful for some clinical applications. The present study investigated properties of fast-setting HA-forming premixed CPCs that initially consisted of two separate premixed pastes: (1) finely ground (1.0 μm in median size) dicalcium phosphate anhydrous (DCPA) mixed with an aqueous NaH(2)PO(4) solution, 1.5 mol/L or 3.0 mol/L in concentration, and (2) tetracalcium phosphate consisting of combinations of particles of two different size distributions, 5 μm (TTCP5) and 17 μm (TTCP17) in median size, mixed with glycerin. Equal volume of Pastes 1 and 2 were injected with the use of atwo-barrel syringe fitted with a static mixer into sample molds. The molar Ca/P ratio of combined paste was approximately 1.5. Cements were characterized in terms of setting time (Gilmore needle), diametral tensile strength (DTS), and phase composition (powder x-ray diffraction, XRD). Setting times were found to range from (4.3 ± 0.6 to 68 ± 3) min (mean ± sd; n = 3), and 1-d and 7-d DTS values were from (0.89 ± 0.08 to 2.44 ± 0.16) MPa (mean ± sd; n = 5). Both the NaH(2)PO(4) concentration and TTCP particle size distribution had significant (p < 0.01) effects on setting time and DTS. Powder XRD analysis showed that low crystallinity HA and unreacted DCPA were present in the 1-day specimens, and the extent of HA formation increased with increasing amount of TTCP5 in the TTCP paste. Conclusion: Injectable HA-forming premixed CPCs with setting times from 4 to 70 min can be prepared by using DCPA and TTCP as the ingredients. Compared to the conventional powder liquid cements, these premixed CPCs have the advantages of being easy to use and having a range of hardening times. [Gaithersburg, MD] : U.S. Dept. of Commerce, National Institute of Standards and Technology 2010 2010-08-01 /pmc/articles/PMC3072679/ /pubmed/21479133 http://dx.doi.org/10.6028/jres.115.017 Text en https://creativecommons.org/publicdomain/zero/1.0/ The Journal of Research of the National Institute of Standards and Technology is a publication of the U.S. Government. The papers are in the public domain and are not subject to copyright in the United States. Articles from J Res may contain photographs or illustrations copyrighted by other commercial organizations or individuals that may not be used without obtaining prior approval from the holder of the copyright. |
spellingShingle | Article Shimada, Yashushi Chow, Laurence C. Takagi, Shozo Tagami, Junji Properties of Injectable Apatite-Forming Premixed Cements |
title | Properties of Injectable Apatite-Forming Premixed Cements |
title_full | Properties of Injectable Apatite-Forming Premixed Cements |
title_fullStr | Properties of Injectable Apatite-Forming Premixed Cements |
title_full_unstemmed | Properties of Injectable Apatite-Forming Premixed Cements |
title_short | Properties of Injectable Apatite-Forming Premixed Cements |
title_sort | properties of injectable apatite-forming premixed cements |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3072679/ https://www.ncbi.nlm.nih.gov/pubmed/21479133 http://dx.doi.org/10.6028/jres.115.017 |
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