In Vitro and in Vivo Characteristics of Fluorapatite-Forming Calcium Phosphate Cements

This study reports for the first time in vitro and in vivo properties of fluorapatite (FA)-forming calcium phosphate cements (CPCs). The experimental cements contained from (0 to 3.1) mass % of F, corresponding to presence of FA at levels of approximately (0 to 87) mass %. The crystallinity of the a...

Descripción completa

Detalles Bibliográficos
Autores principales: Takagi, Shozo, Frukhtbeyn, Stan, Chow, Laurence C., Sugawara, Akiyoshi, Fujikawa, Kenji, Ogata, Hidehiro, Hayashi, Makoto, Ogiso, Binnai
Formato: Texto
Lenguaje:English
Publicado: [Gaithersburg, MD] : U.S. Dept. of Commerce, National Institute of Standards and Technology 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3072690/
https://www.ncbi.nlm.nih.gov/pubmed/21479080
http://dx.doi.org/10.6028/jres.115.020
_version_ 1782201582038810624
author Takagi, Shozo
Frukhtbeyn, Stan
Chow, Laurence C.
Sugawara, Akiyoshi
Fujikawa, Kenji
Ogata, Hidehiro
Hayashi, Makoto
Ogiso, Binnai
author_facet Takagi, Shozo
Frukhtbeyn, Stan
Chow, Laurence C.
Sugawara, Akiyoshi
Fujikawa, Kenji
Ogata, Hidehiro
Hayashi, Makoto
Ogiso, Binnai
author_sort Takagi, Shozo
collection PubMed
description This study reports for the first time in vitro and in vivo properties of fluorapatite (FA)-forming calcium phosphate cements (CPCs). The experimental cements contained from (0 to 3.1) mass % of F, corresponding to presence of FA at levels of approximately (0 to 87) mass %. The crystallinity of the apatitic cement product increased greatly with the FA content. When implanted subcutaneously in rats, the in vivo resorption rate decreased significantly with increasing FA content. The cement with the highest FA content was not resorbed in soft tissue, making it the first known biocompatible and bioinert CPC. These bioinert CPCs might be useful for applications where slow or no resorption of the implant is required to achieve the desired clinical outcome.
format Text
id pubmed-3072690
institution National Center for Biotechnology Information
language English
publishDate 2010
publisher [Gaithersburg, MD] : U.S. Dept. of Commerce, National Institute of Standards and Technology
record_format MEDLINE/PubMed
spelling pubmed-30726902011-04-08 In Vitro and in Vivo Characteristics of Fluorapatite-Forming Calcium Phosphate Cements Takagi, Shozo Frukhtbeyn, Stan Chow, Laurence C. Sugawara, Akiyoshi Fujikawa, Kenji Ogata, Hidehiro Hayashi, Makoto Ogiso, Binnai J Res Natl Inst Stand Technol Article This study reports for the first time in vitro and in vivo properties of fluorapatite (FA)-forming calcium phosphate cements (CPCs). The experimental cements contained from (0 to 3.1) mass % of F, corresponding to presence of FA at levels of approximately (0 to 87) mass %. The crystallinity of the apatitic cement product increased greatly with the FA content. When implanted subcutaneously in rats, the in vivo resorption rate decreased significantly with increasing FA content. The cement with the highest FA content was not resorbed in soft tissue, making it the first known biocompatible and bioinert CPC. These bioinert CPCs might be useful for applications where slow or no resorption of the implant is required to achieve the desired clinical outcome. [Gaithersburg, MD] : U.S. Dept. of Commerce, National Institute of Standards and Technology 2010 2010-08-01 /pmc/articles/PMC3072690/ /pubmed/21479080 http://dx.doi.org/10.6028/jres.115.020 Text en https://creativecommons.org/publicdomain/zero/1.0/ The Journal of Research of the National Institute of Standards and Technology is a publication of the U.S. Government. The papers are in the public domain and are not subject to copyright in the United States. Articles from J Res may contain photographs or illustrations copyrighted by other commercial organizations or individuals that may not be used without obtaining prior approval from the holder of the copyright.
spellingShingle Article
Takagi, Shozo
Frukhtbeyn, Stan
Chow, Laurence C.
Sugawara, Akiyoshi
Fujikawa, Kenji
Ogata, Hidehiro
Hayashi, Makoto
Ogiso, Binnai
In Vitro and in Vivo Characteristics of Fluorapatite-Forming Calcium Phosphate Cements
title In Vitro and in Vivo Characteristics of Fluorapatite-Forming Calcium Phosphate Cements
title_full In Vitro and in Vivo Characteristics of Fluorapatite-Forming Calcium Phosphate Cements
title_fullStr In Vitro and in Vivo Characteristics of Fluorapatite-Forming Calcium Phosphate Cements
title_full_unstemmed In Vitro and in Vivo Characteristics of Fluorapatite-Forming Calcium Phosphate Cements
title_short In Vitro and in Vivo Characteristics of Fluorapatite-Forming Calcium Phosphate Cements
title_sort in vitro and in vivo characteristics of fluorapatite-forming calcium phosphate cements
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3072690/
https://www.ncbi.nlm.nih.gov/pubmed/21479080
http://dx.doi.org/10.6028/jres.115.020
work_keys_str_mv AT takagishozo invitroandinvivocharacteristicsoffluorapatiteformingcalciumphosphatecements
AT frukhtbeynstan invitroandinvivocharacteristicsoffluorapatiteformingcalciumphosphatecements
AT chowlaurencec invitroandinvivocharacteristicsoffluorapatiteformingcalciumphosphatecements
AT sugawaraakiyoshi invitroandinvivocharacteristicsoffluorapatiteformingcalciumphosphatecements
AT fujikawakenji invitroandinvivocharacteristicsoffluorapatiteformingcalciumphosphatecements
AT ogatahidehiro invitroandinvivocharacteristicsoffluorapatiteformingcalciumphosphatecements
AT hayashimakoto invitroandinvivocharacteristicsoffluorapatiteformingcalciumphosphatecements
AT ogisobinnai invitroandinvivocharacteristicsoffluorapatiteformingcalciumphosphatecements

Ejemplares similares