Cargando…
Skeletonized coronary arteries: pathophysiological and clinical aspects of vascular calcification
The role of calcification in coronary artery disease is gaining importance, both in research studies and in clinical application. Calcified plaque has long been considered to be the most important atherosclerotic plaque within the arterial tree and frequently presents a challenge for percutaneous in...
Autores principales: | , , , , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2011
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3072737/ https://www.ncbi.nlm.nih.gov/pubmed/21490939 http://dx.doi.org/10.2147/VHRM.S16328 |
_version_ | 1782201582980431872 |
---|---|
author | Serrano, Carlos V Oranges, Marcelo Brunaldi, Vitor de M Soeiro, Alexandre Torres, Tatiana Andreucci Nicolau, José Carlos Ramires, José Antonio F |
author_facet | Serrano, Carlos V Oranges, Marcelo Brunaldi, Vitor de M Soeiro, Alexandre Torres, Tatiana Andreucci Nicolau, José Carlos Ramires, José Antonio F |
author_sort | Serrano, Carlos V |
collection | PubMed |
description | The role of calcification in coronary artery disease is gaining importance, both in research studies and in clinical application. Calcified plaque has long been considered to be the most important atherosclerotic plaque within the arterial tree and frequently presents a challenge for percutaneous intervention. Current investigations have shown that plaque calcification has a dynamic course that is closely related to the magnitude of vascular inflammation. Numerous inflammatory factors synthesized during the early stages of atherosclerosis induce the expression and activation of osteoblast-like cells localized in the arterial wall that produce calcium. There is no doubt that the role of these factors in calcification associated with coronary artery disease could be a crucial strategic point in prevention and treatment. A number of diagnostic imaging methods have been developed in recent years, but their performance needs to be improved. In this context, we undertook an update on coronary calcification, focusing on physiopathology, clinical implications, and imaging techniques. |
format | Text |
id | pubmed-3072737 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-30727372011-04-13 Skeletonized coronary arteries: pathophysiological and clinical aspects of vascular calcification Serrano, Carlos V Oranges, Marcelo Brunaldi, Vitor de M Soeiro, Alexandre Torres, Tatiana Andreucci Nicolau, José Carlos Ramires, José Antonio F Vasc Health Risk Manag Review The role of calcification in coronary artery disease is gaining importance, both in research studies and in clinical application. Calcified plaque has long been considered to be the most important atherosclerotic plaque within the arterial tree and frequently presents a challenge for percutaneous intervention. Current investigations have shown that plaque calcification has a dynamic course that is closely related to the magnitude of vascular inflammation. Numerous inflammatory factors synthesized during the early stages of atherosclerosis induce the expression and activation of osteoblast-like cells localized in the arterial wall that produce calcium. There is no doubt that the role of these factors in calcification associated with coronary artery disease could be a crucial strategic point in prevention and treatment. A number of diagnostic imaging methods have been developed in recent years, but their performance needs to be improved. In this context, we undertook an update on coronary calcification, focusing on physiopathology, clinical implications, and imaging techniques. Dove Medical Press 2011 2011-03-09 /pmc/articles/PMC3072737/ /pubmed/21490939 http://dx.doi.org/10.2147/VHRM.S16328 Text en © 2011 Serrano et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited. |
spellingShingle | Review Serrano, Carlos V Oranges, Marcelo Brunaldi, Vitor de M Soeiro, Alexandre Torres, Tatiana Andreucci Nicolau, José Carlos Ramires, José Antonio F Skeletonized coronary arteries: pathophysiological and clinical aspects of vascular calcification |
title | Skeletonized coronary arteries: pathophysiological and clinical aspects of vascular calcification |
title_full | Skeletonized coronary arteries: pathophysiological and clinical aspects of vascular calcification |
title_fullStr | Skeletonized coronary arteries: pathophysiological and clinical aspects of vascular calcification |
title_full_unstemmed | Skeletonized coronary arteries: pathophysiological and clinical aspects of vascular calcification |
title_short | Skeletonized coronary arteries: pathophysiological and clinical aspects of vascular calcification |
title_sort | skeletonized coronary arteries: pathophysiological and clinical aspects of vascular calcification |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3072737/ https://www.ncbi.nlm.nih.gov/pubmed/21490939 http://dx.doi.org/10.2147/VHRM.S16328 |
work_keys_str_mv | AT serranocarlosv skeletonizedcoronaryarteriespathophysiologicalandclinicalaspectsofvascularcalcification AT orangesmarcelo skeletonizedcoronaryarteriespathophysiologicalandclinicalaspectsofvascularcalcification AT brunaldivitor skeletonizedcoronaryarteriespathophysiologicalandclinicalaspectsofvascularcalcification AT demsoeiroalexandre skeletonizedcoronaryarteriespathophysiologicalandclinicalaspectsofvascularcalcification AT torrestatianaandreucci skeletonizedcoronaryarteriespathophysiologicalandclinicalaspectsofvascularcalcification AT nicolaujosecarlos skeletonizedcoronaryarteriespathophysiologicalandclinicalaspectsofvascularcalcification AT ramiresjoseantoniof skeletonizedcoronaryarteriespathophysiologicalandclinicalaspectsofvascularcalcification |