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Doppler study of cerebral arteries in hypercholesterolemia

BACKGROUND: Hypercholesterolemia is one of the major modifiable risk factors for atherosclerosis of the coronary and carotid arteries. Although transcranial Doppler (TCD) studies of the cerebral arteries are indicative of decreased cerebral blood flow velocities in patients with hypercholesterolemia...

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Autores principales: Farhoudi, Mehdi, Mehrvar, Kaveh, Aslanabadi, Naser, Ghabili, Kamyar, Baghmishe, Nazila Rasi, Ilkhchoei, Farzad
Formato: Texto
Lenguaje:English
Publicado: Dove Medical Press 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3072744/
https://www.ncbi.nlm.nih.gov/pubmed/21490946
http://dx.doi.org/10.2147/VHRM.S18663
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author Farhoudi, Mehdi
Mehrvar, Kaveh
Aslanabadi, Naser
Ghabili, Kamyar
Baghmishe, Nazila Rasi
Ilkhchoei, Farzad
author_facet Farhoudi, Mehdi
Mehrvar, Kaveh
Aslanabadi, Naser
Ghabili, Kamyar
Baghmishe, Nazila Rasi
Ilkhchoei, Farzad
author_sort Farhoudi, Mehdi
collection PubMed
description BACKGROUND: Hypercholesterolemia is one of the major modifiable risk factors for atherosclerosis of the coronary and carotid arteries. Although transcranial Doppler (TCD) studies of the cerebral arteries are indicative of decreased cerebral blood flow velocities in patients with hypercholesterolemia, the number of these studies has been limited. The aim of this study was to assess the hemodynamic status of the cerebral arteries in patients with hypercholesterolemia using TCD. METHODS: In a case-control study, 60 individuals, including 30 hypercholesterolemic cases (low-density lipoprotein [LDL] > 160 mg/dL) and 30 healthy controls were enrolled. Other arterial risk factors, including diabetes mellitus, hypertension, smoking, and obesity (body mass index > 30), were evaluated and matched as well. TCD was used to assess the hemodynamics of the intracranial arteries as well as the internal carotid arteries. The mean blood flow velocity, pulsatility index, and resistance index were recorded in all the arteries. RESULTS: The mean blood flow velocity, pulsatility index, and resistance index of the intracranial arteries and internal carotid arteries were not significantly different between the two groups (P > 0.05). However, those with higher levels of LDL (>180 mg/dL) showed significantly lower mean blood flow velocity and resistance index of the internal carotid arteries than the healthy controls. In addition, individuals with high-density lipoprotein (HDL) <35 mg/dL had significantly lower mean blood flow velocity in the internal carotid arteries. CONCLUSION: Hypercholesterolemia (LDL >160 mg/dL) does not seem to have a detrimental effect on the hemodynamic status of the intracranial arteries and internal carotid arteries. However, in cases of higher LDL (>180 mg/dL) and lower HDL, decreased TCD parameters in the internal carotid arteries, as a surrogate of the peripheral arteries, are prominent.
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spelling pubmed-30727442011-04-13 Doppler study of cerebral arteries in hypercholesterolemia Farhoudi, Mehdi Mehrvar, Kaveh Aslanabadi, Naser Ghabili, Kamyar Baghmishe, Nazila Rasi Ilkhchoei, Farzad Vasc Health Risk Manag Original Research BACKGROUND: Hypercholesterolemia is one of the major modifiable risk factors for atherosclerosis of the coronary and carotid arteries. Although transcranial Doppler (TCD) studies of the cerebral arteries are indicative of decreased cerebral blood flow velocities in patients with hypercholesterolemia, the number of these studies has been limited. The aim of this study was to assess the hemodynamic status of the cerebral arteries in patients with hypercholesterolemia using TCD. METHODS: In a case-control study, 60 individuals, including 30 hypercholesterolemic cases (low-density lipoprotein [LDL] > 160 mg/dL) and 30 healthy controls were enrolled. Other arterial risk factors, including diabetes mellitus, hypertension, smoking, and obesity (body mass index > 30), were evaluated and matched as well. TCD was used to assess the hemodynamics of the intracranial arteries as well as the internal carotid arteries. The mean blood flow velocity, pulsatility index, and resistance index were recorded in all the arteries. RESULTS: The mean blood flow velocity, pulsatility index, and resistance index of the intracranial arteries and internal carotid arteries were not significantly different between the two groups (P > 0.05). However, those with higher levels of LDL (>180 mg/dL) showed significantly lower mean blood flow velocity and resistance index of the internal carotid arteries than the healthy controls. In addition, individuals with high-density lipoprotein (HDL) <35 mg/dL had significantly lower mean blood flow velocity in the internal carotid arteries. CONCLUSION: Hypercholesterolemia (LDL >160 mg/dL) does not seem to have a detrimental effect on the hemodynamic status of the intracranial arteries and internal carotid arteries. However, in cases of higher LDL (>180 mg/dL) and lower HDL, decreased TCD parameters in the internal carotid arteries, as a surrogate of the peripheral arteries, are prominent. Dove Medical Press 2011 2011-03-31 /pmc/articles/PMC3072744/ /pubmed/21490946 http://dx.doi.org/10.2147/VHRM.S18663 Text en © 2011 Farhoudi et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.
spellingShingle Original Research
Farhoudi, Mehdi
Mehrvar, Kaveh
Aslanabadi, Naser
Ghabili, Kamyar
Baghmishe, Nazila Rasi
Ilkhchoei, Farzad
Doppler study of cerebral arteries in hypercholesterolemia
title Doppler study of cerebral arteries in hypercholesterolemia
title_full Doppler study of cerebral arteries in hypercholesterolemia
title_fullStr Doppler study of cerebral arteries in hypercholesterolemia
title_full_unstemmed Doppler study of cerebral arteries in hypercholesterolemia
title_short Doppler study of cerebral arteries in hypercholesterolemia
title_sort doppler study of cerebral arteries in hypercholesterolemia
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3072744/
https://www.ncbi.nlm.nih.gov/pubmed/21490946
http://dx.doi.org/10.2147/VHRM.S18663
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